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SMILES: CC(=O)Nc1cc(ncn1)-c1ccc(Cl)c(Cl)c1

InChI Key: InChIKey=HMGYWURGEBLZQV-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50072117   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Kynurenine 3-monooxygenase


(Homo sapiens (Human))		BDBM50072117
PNG
(CHEMBL3407898)
Show SMILES CC(=O)Nc1cc(ncn1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C12H9Cl2N3O/c1-7(18)17-12-5-11(15-6-16-12)8-2-3-9(13)10(14)4-8/h2-6H,1H3,(H,15,16,17,18)
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Article
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n/an/a>1.00E+4n/an/an/an/an/an/a



Evotec (U.K.) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis

J Med Chem 58: 1159-83 (2015)


Article DOI: 10.1021/jm501350y
BindingDB Entry DOI: 10.7270/Q2445P5N
More data for this
Ligand-Target Pair