BDBM50072190 (R)-8-Chloro-4,10b-dimethyl-1,5,6,10b-tetrahydro-2H-phenanthridin-3-one::CHEMBL97266
SMILES: CC1C(=O)CC[C@@]2(C)C1=NCc1cc(Cl)ccc21
InChI Key: InChIKey=WYNJQDIVXRFKCM-NZDRZINCSA-N
Data: 4 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5α-Reductase 1 (5α-R1) (Homo sapiens (Human)) | BDBM50072190 ((R)-8-Chloro-4,10b-dimethyl-1,5,6,10b-tetrahydro-2...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 920 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Firenze Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of human Steroid 5-alpha-reductase type 1 | Bioorg Med Chem Lett 8: 2871-6 (1999) BindingDB Entry DOI: 10.7270/Q2CC1169 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5α-Reductase 1 (5α-R1) (Homo sapiens (Human)) | BDBM50072190 ((R)-8-Chloro-4,10b-dimethyl-1,5,6,10b-tetrahydro-2...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article | 920 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of type-1 human steroid 5-alpha-reductase | Bioorg Med Chem Lett 6: 481-484 (1996) Article DOI: 10.1016/0960-894X(96)00054-6 BindingDB Entry DOI: 10.7270/Q2BZ661K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Steroid 5-alpha-reductase (Homo sapiens (Human)) | BDBM50072190 ((R)-8-Chloro-4,10b-dimethyl-1,5,6,10b-tetrahydro-2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of type-2 human steroid 5-alpha-reductase. | Bioorg Med Chem Lett 6: 481-484 (1996) Article DOI: 10.1016/0960-894X(96)00054-6 BindingDB Entry DOI: 10.7270/Q2BZ661K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Steroid 5-alpha-reductase (Homo sapiens (Human)) | BDBM50072190 ((R)-8-Chloro-4,10b-dimethyl-1,5,6,10b-tetrahydro-2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Firenze Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of human Steroid 5-alpha-reductase type 2 | Bioorg Med Chem Lett 8: 2871-6 (1999) BindingDB Entry DOI: 10.7270/Q2CC1169 | |||||||||||
More data for this Ligand-Target Pair |