BindingDB PrimarySearch

BDBM50072209 3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydroxy-ethoxy)-6-methoxy-quinazolin-2-ylamino]-propan-1-ol::CHEMBL97785

SMILES: COc1cc2c(nc(NCCCO)nc2cc1OCCO)-c1cc(OCC2CC2)cc(OCC2CC2)c1

InChI Key: InChIKey=FQHZXMKFQOKAPD-UHFFFAOYSA-N

Data: 5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50072209
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (RAT)	BDBM50072209 (3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharma AG Curated by ChEMBL					Assay Description Evaluated for its ability to inhibit PDE4B.				Bioorg Med Chem Lett 8: 2891-6 (1999) BindingDB Entry DOI: 10.7270/Q2PG1QVX
Novartis Pharma AG Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50072209 (3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharma AG Curated by ChEMBL					Assay Description Evaluated for its ability to inhibit PDE4D.				Bioorg Med Chem Lett 8: 2891-6 (1999) BindingDB Entry DOI: 10.7270/Q2PG1QVX
Novartis Pharma AG Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphodiesterase 4 (RAT-Rattus norvegicus)	BDBM50072209 (3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharma AG Curated by ChEMBL					Assay Description Evaluated for the inhibition of [3H]rolipram binding to membrane-bound PDE4.				Bioorg Med Chem Lett 8: 2891-6 (1999) BindingDB Entry DOI: 10.7270/Q2PG1QVX
Novartis Pharma AG Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphodiesterase 3 (Homo sapiens (Human))	BDBM50072209 (3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharma AG Curated by ChEMBL					Assay Description Evaluated for its ability to inhibit PDE3.				Bioorg Med Chem Lett 8: 2891-6 (1999) BindingDB Entry DOI: 10.7270/Q2PG1QVX
Novartis Pharma AG Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM50072209 (3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharma AG Curated by ChEMBL					Assay Description Evaluated for its ability to inhibit PDE4A.				Bioorg Med Chem Lett 8: 2891-6 (1999) BindingDB Entry DOI: 10.7270/Q2PG1QVX
Novartis Pharma AG Curated by ChEMBL					More data for this Ligand-Target Pair