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SMILES: C(Oc1nsnc1C12CN3CC1C2C3)C#Cc1ccccc1

InChI Key: InChIKey=RGULZVLKCSFCSB-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50072233   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50072233 (1-[4-(3-Phenyl-prop-2-ynyloxy)-[1,2,5]thiadiazol-3...) Show SMILES C(Oc1nsnc1C12CN3CC1C2C3)C#Cc1ccccc1 Show InChI InChI=1S/C17H15N3OS/c1-2-5-12(6-3-1)7-4-8-21-16-15(18-22-19-16)17-11-20-9-13(17)14(17)10-20/h1-3,5-6,13-14H,8-11H2	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	71	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Stimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptor				Bioorg Med Chem Lett 8: 2897-902 (1999) BindingDB Entry DOI: 10.7270/Q27M08GK
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50072233 (1-[4-(3-Phenyl-prop-2-ynyloxy)-[1,2,5]thiadiazol-3...) Show SMILES C(Oc1nsnc1C12CN3CC1C2C3)C#Cc1ccccc1 Show InChI InChI=1S/C17H15N3OS/c1-2-5-12(6-3-1)7-4-8-21-16-15(18-22-19-16)17-11-20-9-13(17)14(17)10-20/h1-3,5-6,13-14H,8-11H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	779	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Stimulation of cAMP in CHO cells expressing human m2 receptor				Bioorg Med Chem Lett 8: 2897-902 (1999) BindingDB Entry DOI: 10.7270/Q27M08GK
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (RAT)	BDBM50072233 (1-[4-(3-Phenyl-prop-2-ynyloxy)-[1,2,5]thiadiazol-3...) Show SMILES C(Oc1nsnc1C12CN3CC1C2C3)C#Cc1ccccc1 Show InChI InChI=1S/C17H15N3OS/c1-2-5-12(6-3-1)7-4-8-21-16-15(18-22-19-16)17-11-20-9-13(17)14(17)10-20/h1-3,5-6,13-14H,8-11H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Binding affinity against muscarinic receptor in rat brain membranes using oxotremorine-M as ligand				Bioorg Med Chem Lett 8: 2897-902 (1999) BindingDB Entry DOI: 10.7270/Q27M08GK
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50072233 (1-[4-(3-Phenyl-prop-2-ynyloxy)-[1,2,5]thiadiazol-3...) Show SMILES C(Oc1nsnc1C12CN3CC1C2C3)C#Cc1ccccc1 Show InChI InChI=1S/C17H15N3OS/c1-2-5-12(6-3-1)7-4-8-21-16-15(18-22-19-16)17-11-20-9-13(17)14(17)10-20/h1-3,5-6,13-14H,8-11H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	779	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Compound was tested for its potency at Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells				J Med Chem 42: 1999-2006 (1999) Article DOI: 10.1021/jm9910019 BindingDB Entry DOI: 10.7270/Q2XD12BT
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (RAT)	BDBM50072233 (1-[4-(3-Phenyl-prop-2-ynyloxy)-[1,2,5]thiadiazol-3...) Show SMILES C(Oc1nsnc1C12CN3CC1C2C3)C#Cc1ccccc1 Show InChI InChI=1S/C17H15N3OS/c1-2-5-12(6-3-1)7-4-8-21-16-15(18-22-19-16)17-11-20-9-13(17)14(17)10-20/h1-3,5-6,13-14H,8-11H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.				J Med Chem 42: 1999-2006 (1999) Article DOI: 10.1021/jm9910019 BindingDB Entry DOI: 10.7270/Q2XD12BT
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50072233 (1-[4-(3-Phenyl-prop-2-ynyloxy)-[1,2,5]thiadiazol-3...) Show SMILES C(Oc1nsnc1C12CN3CC1C2C3)C#Cc1ccccc1 Show InChI InChI=1S/C17H15N3OS/c1-2-5-12(6-3-1)7-4-8-21-16-15(18-22-19-16)17-11-20-9-13(17)14(17)10-20/h1-3,5-6,13-14H,8-11H2	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	71	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.				J Med Chem 42: 1999-2006 (1999) Article DOI: 10.1021/jm9910019 BindingDB Entry DOI: 10.7270/Q2XD12BT
					More data for this Ligand-Target Pair