BDBM50072796 CHEMBL3410044
SMILES: Cc1c[nH]c2ncnc(-c3ccc(NC(=O)N(CCO)c4cccc(C)c4)cc3)c12
InChI Key: InChIKey=UZLBPADXEZMDBH-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM50072796 (CHEMBL3410044) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 8.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Translational Research Institute Curated by ChEMBL | Assay Description Inhibition of human ROCK2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK peptide substrate, ATP and [gamma33P]ATP | J Med Chem 58: 1846-61 (2015) Article DOI: 10.1021/jm501680m BindingDB Entry DOI: 10.7270/Q2K64KRC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
LIM domain kinase 1 (Homo sapiens (Human)) | BDBM50072796 (CHEMBL3410044) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 151 | n/a | n/a | n/a | n/a | n/a | n/a |
Translational Research Institute Curated by ChEMBL | Assay Description Inhibition of human Limk1 using cofilin substrate, ATP and [gamma33P]ATP | J Med Chem 58: 1846-61 (2015) Article DOI: 10.1021/jm501680m BindingDB Entry DOI: 10.7270/Q2K64KRC | |||||||||||
More data for this Ligand-Target Pair |