BDBM50073316 CHEMBL114715::INOGATRAN::{(R)-1-Cyclohexylmethyl-2-[(S)-2-(3-guanidino-propylcarbamoyl)-piperidin-1-yl]-2-oxo-ethylamino}-acetic acid::{1-Cyclohexylmethyl-2-[2-(3-guanidino-propylcarbamoyl)-piperidin-1-yl]-2-oxo-ethylamino}-acetic acid(inogatran)::{[(1R)-2-((2S)-2-{[(3-{[AMINO(IMINO)METHYL]AMINO}PROPYL)AMINO]CARBONYL}PIPERIDINYL)-1-(CYCLOHEXYLMETHYL)-2-OXOETHYL]AMINO}ACETIC ACID
SMILES: NC(=N)NCCCNC(=O)[C@@H]1CCCCN1C(=O)[C@@H](CC1CCCCC1)NCC(O)=O
InChI Key: InChIKey=CDPROXZBMHOBTQ-SJORKVTESA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prothrombin (Homo sapiens (Human)) | BDBM50073316 (CHEMBL114715 | INOGATRAN | {(R)-1-Cyclohexylmethyl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Boston University Curated by ChEMBL | Assay Description Inhibition of thrombin (unknown origin) | J Med Chem 62: 10005-10025 (2019) Article DOI: 10.1021/acs.jmedchem.8b01732 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM50073316 (CHEMBL114715 | INOGATRAN | {(R)-1-Cyclohexylmethyl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB PubMed | 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Queensland Curated by ChEMBL | Assay Description Binding affinity against Thrombin. | J Med Chem 43: 305-41 (2000) Checked by Author BindingDB Entry DOI: 10.7270/Q2JD4XH4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM50073316 (CHEMBL114715 | INOGATRAN | {(R)-1-Cyclohexylmethyl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB PubMed | 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NV Organon Scientific Development Group Curated by ChEMBL | Assay Description The inhibitory activity of the compound was tested against thrombin (IIa) | Bioorg Med Chem Lett 8: 3603-8 (1999) BindingDB Entry DOI: 10.7270/Q20P0Z5B | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Trypsin (Bos taurus (bovine)) | BDBM50073316 (CHEMBL114715 | INOGATRAN | {(R)-1-Cyclohexylmethyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB PubMed | 675 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NV Organon Scientific Development Group Curated by ChEMBL | Assay Description The inhibitory activity of the compound was tested against trypsin | Bioorg Med Chem Lett 8: 3603-8 (1999) BindingDB Entry DOI: 10.7270/Q20P0Z5B | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM50073316 (CHEMBL114715 | INOGATRAN | {(R)-1-Cyclohexylmethyl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB PubMed | n/a | n/a | 2.24E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Link£ping University Curated by ChEMBL | Assay Description In vitro for the inhibition of thrombin | J Med Chem 43: 1705-13 (2000) BindingDB Entry DOI: 10.7270/Q22808BS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM50073316 (CHEMBL114715 | INOGATRAN | {(R)-1-Cyclohexylmethyl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB PubMed | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NV Organon Scientific Development Group Curated by ChEMBL | Assay Description Inhibition of thrombin (IIa) | Bioorg Med Chem Lett 8: 3603-8 (1999) BindingDB Entry DOI: 10.7270/Q20P0Z5B | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM50073316 (CHEMBL114715 | INOGATRAN | {(R)-1-Cyclohexylmethyl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Queensland Curated by ChEMBL | Assay Description Inhibition against platelet aggregation without interacting directly with the nucleophilic serine of thrombin. | J Med Chem 43: 305-41 (2000) Checked by Author BindingDB Entry DOI: 10.7270/Q2JD4XH4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |