BDBM50074305 4-[[(E)-2-Amino-ethoxyimino]-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid::CHEMBL162876

SMILES: Cc1cc2c(cc1\C(=N\OCCN)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C

InChI Key: InChIKey=OTHOZFHNKHDIEE-HPNDGRJYSA-N

Data: 3 KI  3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50074305   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Retinoid X receptor gamma/retinoic acid receptor alpha (Homo sapiens (Human))	BDBM50074305 (4-[[(E)-2-Amino-ethoxyimino]-(3,5,5,8,8-pentamethy...) Show SMILES Cc1cc2c(cc1\C(=N\OCCN)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C Show InChI InChI=1S/C25H32N2O3/c1-16-14-20-21(25(4,5)11-10-24(20,2)3)15-19(16)22(27-30-13-12-26)17-6-8-18(9-7-17)23(28)29/h6-9,14-15H,10-13,26H2,1-5H3,(H,28,29)/b27-22+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc Curated by ChEMBL					Assay Description Binding affinity towards recombinantly expressed Retinoic acid receptor RXR-gamma in baculoviral sysytem, by using 5 nM [3H]-targretin in a competiti...				J Med Chem 42: 742-50 (1999) Article DOI: 10.1021/jm980621r BindingDB Entry DOI: 10.7270/Q2K936Q1
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha (Homo sapiens (Human))	BDBM50074305 (4-[[(E)-2-Amino-ethoxyimino]-(3,5,5,8,8-pentamethy...) Show SMILES Cc1cc2c(cc1\C(=N\OCCN)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C Show InChI InChI=1S/C25H32N2O3/c1-16-14-20-21(25(4,5)11-10-24(20,2)3)15-19(16)22(27-30-13-12-26)17-6-8-18(9-7-17)23(28)29/h6-9,14-15H,10-13,26H2,1-5H3,(H,28,29)/b27-22+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc Curated by ChEMBL					Assay Description Binding affinity towards recombinantly expressed Retinoic acid receptor RXR-alpha in baculoviral sysytem, by using 5 nM [3H]-targretin in a competiti...				J Med Chem 42: 742-50 (1999) Article DOI: 10.1021/jm980621r BindingDB Entry DOI: 10.7270/Q2K936Q1
					More data for this Ligand-Target Pair
Retinoid receptor (Homo sapiens (Human))	BDBM50074305 (4-[[(E)-2-Amino-ethoxyimino]-(3,5,5,8,8-pentamethy...) Show SMILES Cc1cc2c(cc1\C(=N\OCCN)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C Show InChI InChI=1S/C25H32N2O3/c1-16-14-20-21(25(4,5)11-10-24(20,2)3)15-19(16)22(27-30-13-12-26)17-6-8-18(9-7-17)23(28)29/h6-9,14-15H,10-13,26H2,1-5H3,(H,28,29)/b27-22+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc Curated by ChEMBL					Assay Description Binding affinity towards recombinantly expressed Retinoic acid receptor RXR-beta in baculoviral sysytem, by using 5 nM [3H]-targretin in a competitiv...				J Med Chem 42: 742-50 (1999) Article DOI: 10.1021/jm980621r BindingDB Entry DOI: 10.7270/Q2K936Q1
					More data for this Ligand-Target Pair
Retinoid X receptor gamma/retinoic acid receptor alpha (Homo sapiens (Human))	BDBM50074305 (4-[[(E)-2-Amino-ethoxyimino]-(3,5,5,8,8-pentamethy...) Show SMILES Cc1cc2c(cc1\C(=N\OCCN)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C Show InChI InChI=1S/C25H32N2O3/c1-16-14-20-21(25(4,5)11-10-24(20,2)3)15-19(16)22(27-30-13-12-26)17-6-8-18(9-7-17)23(28)29/h6-9,14-15H,10-13,26H2,1-5H3,(H,28,29)/b27-22+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	306	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc Curated by ChEMBL					Assay Description Transcriptional activity was evaluated in CV-1 cells transfected with expression vector for Retinoic acid receptor RXR-gamma				J Med Chem 42: 742-50 (1999) Article DOI: 10.1021/jm980621r BindingDB Entry DOI: 10.7270/Q2K936Q1
					More data for this Ligand-Target Pair
Retinoid receptor (Homo sapiens (Human))	BDBM50074305 (4-[[(E)-2-Amino-ethoxyimino]-(3,5,5,8,8-pentamethy...) Show SMILES Cc1cc2c(cc1\C(=N\OCCN)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C Show InChI InChI=1S/C25H32N2O3/c1-16-14-20-21(25(4,5)11-10-24(20,2)3)15-19(16)22(27-30-13-12-26)17-6-8-18(9-7-17)23(28)29/h6-9,14-15H,10-13,26H2,1-5H3,(H,28,29)/b27-22+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	61	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc Curated by ChEMBL					Assay Description Transcriptional activity was evaluated in CV-1 cells transfected with expression vector for Retinoic acid receptor RXR-beta				J Med Chem 42: 742-50 (1999) Article DOI: 10.1021/jm980621r BindingDB Entry DOI: 10.7270/Q2K936Q1
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha (Homo sapiens (Human))	BDBM50074305 (4-[[(E)-2-Amino-ethoxyimino]-(3,5,5,8,8-pentamethy...) Show SMILES Cc1cc2c(cc1\C(=N\OCCN)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C Show InChI InChI=1S/C25H32N2O3/c1-16-14-20-21(25(4,5)11-10-24(20,2)3)15-19(16)22(27-30-13-12-26)17-6-8-18(9-7-17)23(28)29/h6-9,14-15H,10-13,26H2,1-5H3,(H,28,29)/b27-22+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	350	n/a	n/a	n/a	n/a
Ligand Pharmaceuticals, Inc Curated by ChEMBL					Assay Description Transcriptional activity was evaluated in CV-1 cells transfected with expression vector for Retinoic acid receptor RXR-alpha				J Med Chem 42: 742-50 (1999) Article DOI: 10.1021/jm980621r BindingDB Entry DOI: 10.7270/Q2K936Q1
					More data for this Ligand-Target Pair