BDBM50074887 1-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthalen-1-yl)-pyridin-2-yl]-1H-quinolin-4-one::CHEMBL274528

SMILES: COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3ccc(=O)c4ccccc34)c2cc1OC

InChI Key: InChIKey=LKQLMGVBCLAGOJ-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50074887   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 3 (Homo sapiens (Human))	BDBM50074887 (1-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...) Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3ccc(=O)c4ccccc34)c2cc1OC Show InChI InChI=1S/C28H24N2O5/c1-34-25-12-18-11-19(15-31)22(16-32)28(21(18)14-26(25)35-2)17-7-9-29-27(13-17)30-10-8-24(33)20-5-3-4-6-23(20)30/h3-14,31-32H,15-16H2,1-2H3	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Company, Ltd. Curated by ChEMBL					Assay Description In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricle				J Med Chem 42: 1088-99 (1999) Article DOI: 10.1021/jm980314l BindingDB Entry DOI: 10.7270/Q25M66DH
					More data for this Ligand-Target Pair
Phosphodiesterase 1 (Homo sapiens (Human))	BDBM50074887 (1-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...) Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3ccc(=O)c4ccccc34)c2cc1OC Show InChI InChI=1S/C28H24N2O5/c1-34-25-12-18-11-19(15-31)22(16-32)28(21(18)14-26(25)35-2)17-7-9-29-27(13-17)30-10-8-24(33)20-5-3-4-6-23(20)30/h3-14,31-32H,15-16H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Company, Ltd. Curated by ChEMBL					Assay Description Inhibition of Phosphodiesterase 1 of guinea pig cardiac ventricle				J Med Chem 42: 1088-99 (1999) Article DOI: 10.1021/jm980314l BindingDB Entry DOI: 10.7270/Q25M66DH
					More data for this Ligand-Target Pair
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50074887 (1-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...) Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3ccc(=O)c4ccccc34)c2cc1OC Show InChI InChI=1S/C28H24N2O5/c1-34-25-12-18-11-19(15-31)22(16-32)28(21(18)14-26(25)35-2)17-7-9-29-27(13-17)30-10-8-24(33)20-5-3-4-6-23(20)30/h3-14,31-32H,15-16H2,1-2H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Company, Ltd. Curated by ChEMBL					Assay Description In vitro inhibition of Phosphodiesterase 4 from guinea pig lung				J Med Chem 42: 1088-99 (1999) Article DOI: 10.1021/jm980314l BindingDB Entry DOI: 10.7270/Q25M66DH
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50074887 (1-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...) Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3ccc(=O)c4ccccc34)c2cc1OC Show InChI InChI=1S/C28H24N2O5/c1-34-25-12-18-11-19(15-31)22(16-32)28(21(18)14-26(25)35-2)17-7-9-29-27(13-17)30-10-8-24(33)20-5-3-4-6-23(20)30/h3-14,31-32H,15-16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Company, Ltd. Curated by ChEMBL					Assay Description Inhibition of Phosphodiesterase 5 of guinea pig lung				J Med Chem 42: 1088-99 (1999) Article DOI: 10.1021/jm980314l BindingDB Entry DOI: 10.7270/Q25M66DH
					More data for this Ligand-Target Pair