BDBM50075148 (E)-N-[(S)-1-(5-Methyl-4-oxo-4H-thieno[2,3-d][1,3]oxazin-2-yl)-ethyl]-3-(1-methyl-1H-pyrrol-2-yl)-acrylamide::CHEMBL138479
SMILES: C[C@H](NC(=O)\C=C\c1cccn1C)c1nc2scc(C)c2c(=O)o1
InChI Key: InChIKey=KCYKLHNWERQWPY-MLRMMBSGSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Human herpesvirus 2 protease (Human herpesvirus 2 (strain HG52) (HHV-2) (Human h...) | BDBM50075148 ((E)-N-[(S)-1-(5-Methyl-4-oxo-4H-thieno[2,3-d][1,3]...) | MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Inhibitory activity against herpes simplex virus type 2 (HSV-2) protease was determined using quenched fluorescence assay | Bioorg Med Chem Lett 9: 443-8 (1999) BindingDB Entry DOI: 10.7270/Q2ZC822V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Human herpesvirus 4 protease/capsid scaffold protein (Epstein-Barr virus (strain B95-8) (HHV-4) (Human h...) | BDBM50075148 ((E)-N-[(S)-1-(5-Methyl-4-oxo-4H-thieno[2,3-d][1,3]...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Inhibitory activity against cytomegalovirus (CMV) protease was determined using quenched fluorescence assay | Bioorg Med Chem Lett 9: 443-8 (1999) BindingDB Entry DOI: 10.7270/Q2ZC822V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Human herpesvirus 6 protease (Human herpesvirus 6A (strain Uganda-1102) (HHV-6 v...) | BDBM50075148 ((E)-N-[(S)-1-(5-Methyl-4-oxo-4H-thieno[2,3-d][1,3]...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Inhibitory activity against Varicella Zoster Virus (VZV) protease was determined using quenched fluorescence assay | Bioorg Med Chem Lett 9: 443-8 (1999) BindingDB Entry DOI: 10.7270/Q2ZC822V | |||||||||||
More data for this Ligand-Target Pair |