BDBM50075208 CHEMBL3414860

SMILES: ON1C(=O)Cc2cc(Cc3ccc(Cl)cc3)ccc2C1=O

InChI Key: InChIKey=PSTMPEQPXUWBFA-UHFFFAOYSA-N

Data: 13 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50075208   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50075208 (CHEMBL3414860) Show SMILES ON1C(=O)Cc2cc(Cc3ccc(Cl)cc3)ccc2C1=O Show InChI InChI=1S/C16H12ClNO3/c17-13-4-1-10(2-5-13)7-11-3-6-14-12(8-11)9-15(19)18(21)16(14)20/h1-6,8,21H,7,9H2	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of HIV1 reverse transcriptase L100I/K103N mutant polymerase activity using [3H]TTP and poly(rA)-oligo(dT)16 substrate incubated for 20 min...				J Med Chem 58: 651-64 (2015) Article DOI: 10.1021/jm501132s BindingDB Entry DOI: 10.7270/Q2W95BWG
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50075208 (CHEMBL3414860) Show SMILES ON1C(=O)Cc2cc(Cc3ccc(Cl)cc3)ccc2C1=O Show InChI InChI=1S/C16H12ClNO3/c17-13-4-1-10(2-5-13)7-11-3-6-14-12(8-11)9-15(19)18(21)16(14)20/h1-6,8,21H,7,9H2	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of Moloney murine leukemia virus reverse transcriptase polymerase activity using Td100/Pd18 DNA-DNA substrate incubated for 30 mins by flu...				J Med Chem 58: 651-64 (2015) Article DOI: 10.1021/jm501132s BindingDB Entry DOI: 10.7270/Q2W95BWG
					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50075208 (CHEMBL3414860) Show SMILES ON1C(=O)Cc2cc(Cc3ccc(Cl)cc3)ccc2C1=O Show InChI InChI=1S/C16H12ClNO3/c17-13-4-1-10(2-5-13)7-11-3-6-14-12(8-11)9-15(19)18(21)16(14)20/h1-6,8,21H,7,9H2	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of HIV integrase pre-incubated for 10 mins before DNA substrate addition				J Med Chem 58: 651-64 (2015) Article DOI: 10.1021/jm501132s BindingDB Entry DOI: 10.7270/Q2W95BWG
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50075208 (CHEMBL3414860) Show SMILES ON1C(=O)Cc2cc(Cc3ccc(Cl)cc3)ccc2C1=O Show InChI InChI=1S/C16H12ClNO3/c17-13-4-1-10(2-5-13)7-11-3-6-14-12(8-11)9-15(19)18(21)16(14)20/h1-6,8,21H,7,9H2	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of HIV1 recombinant reverse transcriptase associated catalytically active RNase H domain assessed as reduction in DNA 3' end directed clea...				J Med Chem 58: 651-64 (2015) Article DOI: 10.1021/jm501132s BindingDB Entry DOI: 10.7270/Q2W95BWG
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50075208 (CHEMBL3414860) Show SMILES ON1C(=O)Cc2cc(Cc3ccc(Cl)cc3)ccc2C1=O Show InChI InChI=1S/C16H12ClNO3/c17-13-4-1-10(2-5-13)7-11-3-6-14-12(8-11)9-15(19)18(21)16(14)20/h1-6,8,21H,7,9H2	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of HIV1 recombinant reverse transcriptase associated catalytically active RNase H domain assessed as reduction in internal cleavage using ...				J Med Chem 58: 651-64 (2015) Article DOI: 10.1021/jm501132s BindingDB Entry DOI: 10.7270/Q2W95BWG
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50075208 (CHEMBL3414860) Show SMILES ON1C(=O)Cc2cc(Cc3ccc(Cl)cc3)ccc2C1=O Show InChI InChI=1S/C16H12ClNO3/c17-13-4-1-10(2-5-13)7-11-3-6-14-12(8-11)9-15(19)18(21)16(14)20/h1-6,8,21H,7,9H2	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of HIV1 recombinant reverse transcriptase associated catalytically active RNase H domain assessed as reduction in RNA 5' end directed clea...				J Med Chem 58: 651-64 (2015) Article DOI: 10.1021/jm501132s BindingDB Entry DOI: 10.7270/Q2W95BWG
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50075208 (CHEMBL3414860) Show SMILES ON1C(=O)Cc2cc(Cc3ccc(Cl)cc3)ccc2C1=O Show InChI InChI=1S/C16H12ClNO3/c17-13-4-1-10(2-5-13)7-11-3-6-14-12(8-11)9-15(19)18(21)16(14)20/h1-6,8,21H,7,9H2	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of HIV1 reverse transcriptase L100I/K103N mutant associated RNase H domain activity assessed as reduction in reduction in DNA 3' end direc...				J Med Chem 58: 651-64 (2015) Article DOI: 10.1021/jm501132s BindingDB Entry DOI: 10.7270/Q2W95BWG
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50075208 (CHEMBL3414860) Show SMILES ON1C(=O)Cc2cc(Cc3ccc(Cl)cc3)ccc2C1=O Show InChI InChI=1S/C16H12ClNO3/c17-13-4-1-10(2-5-13)7-11-3-6-14-12(8-11)9-15(19)18(21)16(14)20/h1-6,8,21H,7,9H2	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of HIV1 recombinant reverse transcriptase polymerase activity using [3H]TTP and poly(rA)-oligo(dT)16 substrate incubated for 20 mins by li...				J Med Chem 58: 651-64 (2015) Article DOI: 10.1021/jm501132s BindingDB Entry DOI: 10.7270/Q2W95BWG
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50075208 (CHEMBL3414860) Show SMILES ON1C(=O)Cc2cc(Cc3ccc(Cl)cc3)ccc2C1=O Show InChI InChI=1S/C16H12ClNO3/c17-13-4-1-10(2-5-13)7-11-3-6-14-12(8-11)9-15(19)18(21)16(14)20/h1-6,8,21H,7,9H2	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of HIV1 reverse transcriptase Y181C mutant associated RNase H domain activity assessed as reduction in internal cleavage using HTS-1 RNA/D...				J Med Chem 58: 651-64 (2015) Article DOI: 10.1021/jm501132s BindingDB Entry DOI: 10.7270/Q2W95BWG
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50075208 (CHEMBL3414860) Show SMILES ON1C(=O)Cc2cc(Cc3ccc(Cl)cc3)ccc2C1=O Show InChI InChI=1S/C16H12ClNO3/c17-13-4-1-10(2-5-13)7-11-3-6-14-12(8-11)9-15(19)18(21)16(14)20/h1-6,8,21H,7,9H2	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of HIV1 reverse transcriptase Y181C mutant associated RNase H domain activity assessed as reduction in reduction in DNA 3' end directed cl...				J Med Chem 58: 651-64 (2015) Article DOI: 10.1021/jm501132s BindingDB Entry DOI: 10.7270/Q2W95BWG
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50075208 (CHEMBL3414860) Show SMILES ON1C(=O)Cc2cc(Cc3ccc(Cl)cc3)ccc2C1=O Show InChI InChI=1S/C16H12ClNO3/c17-13-4-1-10(2-5-13)7-11-3-6-14-12(8-11)9-15(19)18(21)16(14)20/h1-6,8,21H,7,9H2	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of HIV1 reverse transcriptase Y181C mutant polymerase activity using [3H]TTP and poly(rA)-oligo(dT)16 substrate incubated for 20 mins by l...				J Med Chem 58: 651-64 (2015) Article DOI: 10.1021/jm501132s BindingDB Entry DOI: 10.7270/Q2W95BWG
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50075208 (CHEMBL3414860) Show SMILES ON1C(=O)Cc2cc(Cc3ccc(Cl)cc3)ccc2C1=O Show InChI InChI=1S/C16H12ClNO3/c17-13-4-1-10(2-5-13)7-11-3-6-14-12(8-11)9-15(19)18(21)16(14)20/h1-6,8,21H,7,9H2	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of HIV1 reverse transcriptase L100I/K103N mutant associated RNase H domain activity assessed as reduction in internal cleavage using HTS-1...				J Med Chem 58: 651-64 (2015) Article DOI: 10.1021/jm501132s BindingDB Entry DOI: 10.7270/Q2W95BWG
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50075208 (CHEMBL3414860) Show SMILES ON1C(=O)Cc2cc(Cc3ccc(Cl)cc3)ccc2C1=O Show InChI InChI=1S/C16H12ClNO3/c17-13-4-1-10(2-5-13)7-11-3-6-14-12(8-11)9-15(19)18(21)16(14)20/h1-6,8,21H,7,9H2	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of reconstituted HIV1 RNase H using RNA/DNA duplex substrate by fluorescence assay				J Med Chem 58: 651-64 (2015) Article DOI: 10.1021/jm501132s BindingDB Entry DOI: 10.7270/Q2W95BWG
					More data for this Ligand-Target Pair