BDBM50075219 CHEMBL3414866

SMILES: ON1C(=O)Cc2cc(Cc3ccc(cc3)-c3cccs3)ccc2C1=O

InChI Key: InChIKey=NKZFSAJZQUZCNL-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50075219   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Integrase (Human immunodeficiency virus 1)	BDBM50075219 (CHEMBL3414866) Show SMILES ON1C(=O)Cc2cc(Cc3ccc(cc3)-c3cccs3)ccc2C1=O Show InChI InChI=1S/C20H15NO3S/c22-19-12-16-11-14(5-8-17(16)20(23)21(19)24)10-13-3-6-15(7-4-13)18-2-1-9-25-18/h1-9,11,24H,10,12H2	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of HIV integrase pre-incubated for 10 mins before DNA substrate addition				J Med Chem 58: 651-64 (2015) Article DOI: 10.1021/jm501132s BindingDB Entry DOI: 10.7270/Q2W95BWG
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50075219 (CHEMBL3414866) Show SMILES ON1C(=O)Cc2cc(Cc3ccc(cc3)-c3cccs3)ccc2C1=O Show InChI InChI=1S/C20H15NO3S/c22-19-12-16-11-14(5-8-17(16)20(23)21(19)24)10-13-3-6-15(7-4-13)18-2-1-9-25-18/h1-9,11,24H,10,12H2	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of HIV1 recombinant reverse transcriptase associated catalytically active RNase H domain assessed as reduction in DNA 3' end directed clea...				J Med Chem 58: 651-64 (2015) Article DOI: 10.1021/jm501132s BindingDB Entry DOI: 10.7270/Q2W95BWG
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50075219 (CHEMBL3414866) Show SMILES ON1C(=O)Cc2cc(Cc3ccc(cc3)-c3cccs3)ccc2C1=O Show InChI InChI=1S/C20H15NO3S/c22-19-12-16-11-14(5-8-17(16)20(23)21(19)24)10-13-3-6-15(7-4-13)18-2-1-9-25-18/h1-9,11,24H,10,12H2	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of HIV1 recombinant reverse transcriptase polymerase activity using [3H]TTP and poly(rA)-oligo(dT)16 substrate incubated for 20 mins by li...				J Med Chem 58: 651-64 (2015) Article DOI: 10.1021/jm501132s BindingDB Entry DOI: 10.7270/Q2W95BWG
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50075219 (CHEMBL3414866) Show SMILES ON1C(=O)Cc2cc(Cc3ccc(cc3)-c3cccs3)ccc2C1=O Show InChI InChI=1S/C20H15NO3S/c22-19-12-16-11-14(5-8-17(16)20(23)21(19)24)10-13-3-6-15(7-4-13)18-2-1-9-25-18/h1-9,11,24H,10,12H2	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of HIV1 recombinant reverse transcriptase associated catalytically active RNase H domain assessed as reduction in RNA 5' end directed clea...				J Med Chem 58: 651-64 (2015) Article DOI: 10.1021/jm501132s BindingDB Entry DOI: 10.7270/Q2W95BWG
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50075219 (CHEMBL3414866) Show SMILES ON1C(=O)Cc2cc(Cc3ccc(cc3)-c3cccs3)ccc2C1=O Show InChI InChI=1S/C20H15NO3S/c22-19-12-16-11-14(5-8-17(16)20(23)21(19)24)10-13-3-6-15(7-4-13)18-2-1-9-25-18/h1-9,11,24H,10,12H2	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of reconstituted HIV1 RNase H using RNA/DNA duplex substrate by fluorescence assay				J Med Chem 58: 651-64 (2015) Article DOI: 10.1021/jm501132s BindingDB Entry DOI: 10.7270/Q2W95BWG
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50075219 (CHEMBL3414866) Show SMILES ON1C(=O)Cc2cc(Cc3ccc(cc3)-c3cccs3)ccc2C1=O Show InChI InChI=1S/C20H15NO3S/c22-19-12-16-11-14(5-8-17(16)20(23)21(19)24)10-13-3-6-15(7-4-13)18-2-1-9-25-18/h1-9,11,24H,10,12H2	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of HIV1 recombinant reverse transcriptase associated catalytically active RNase H domain assessed as reduction in internal cleavage using ...				J Med Chem 58: 651-64 (2015) Article DOI: 10.1021/jm501132s BindingDB Entry DOI: 10.7270/Q2W95BWG
					More data for this Ligand-Target Pair