BindingDB PrimarySearch

BDBM50075328 2-(2,6-Diisopropyl-phenyl)-5-hydroxy-isoindole-1,3-dione::2-(2,6-diisopropylphenyl)-5-hydroxyisoindoline-1,3-dione::CHEMBL313952

SMILES: CC(C)c1cccc(C(C)C)c1N1C(=O)c2ccc(O)cc2C1=O

InChI Key: InChIKey=LAKWINYVWJPHQW-UHFFFAOYSA-N

Data: 7 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50075328
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50075328 (2-(2,6-Diisopropyl-phenyl)-5-hydroxy-isoindole-1,3...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
University of Tokyo Curated by ChEMBL					Assay Description Inhibitory activity against Dipeptidylpeptidase IV (DPP IV) in human acute lymphoblastic leukemia MOLT-4 cell line				Bioorg Med Chem Lett 9: 559-62 (1999) BindingDB Entry DOI: 10.7270/Q2ZW1MFX
University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50075328 (2-(2,6-Diisopropyl-phenyl)-5-hydroxy-isoindole-1,3...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	6.59E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Tokyo Curated by ChEMBL					Assay Description Inhibitory activity against Dipeptidylpeptidase IV (DPP IV) in human acute lymphoblastic leukemia MOLT-4 cell line				Bioorg Med Chem Lett 9: 559-62 (1999) BindingDB Entry DOI: 10.7270/Q2ZW1MFX
University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase N (Homo sapiens (Human))	BDBM50075328 (2-(2,6-Diisopropyl-phenyl)-5-hydroxy-isoindole-1,3...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	4.64E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Tokyo Curated by ChEMBL					Assay Description Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line				Bioorg Med Chem Lett 9: 559-62 (1999) BindingDB Entry DOI: 10.7270/Q2ZW1MFX
University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase (Homo sapiens (Human))	BDBM50075328 (2-(2,6-Diisopropyl-phenyl)-5-hydroxy-isoindole-1,3...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.63E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Tokyo Curated by ChEMBL					Assay Description Inhibitory activity against aminopeptidase N assayed by the L-Ala-MCA method.				J Med Chem 41: 263-5 (1998) Article DOI: 10.1021/jm970624o BindingDB Entry DOI: 10.7270/Q24X5BJC
University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair
Tubulin beta chain (Sus scrofa)	BDBM50075328 (2-(2,6-Diisopropyl-phenyl)-5-hydroxy-isoindole-1,3...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Tokyo Curated by ChEMBL					Assay Description Inhibition of tubulin polymerization in porcine brain				Bioorg Med Chem Lett 16: 4748-51 (2006) Article DOI: 10.1016/j.bmcl.2006.06.091 BindingDB Entry DOI: 10.7270/Q2PG1VGN
The University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50075328 (2-(2,6-Diisopropyl-phenyl)-5-hydroxy-isoindole-1,3...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.49E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Tokyo Curated by ChEMBL					Assay Description Inhibitory activity against dipeptidyl peptidase IV (DPP- IV)				J Med Chem 41: 263-5 (1998) Article DOI: 10.1021/jm970624o BindingDB Entry DOI: 10.7270/Q24X5BJC
University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase (Homo sapiens (Human))	BDBM50075328 (2-(2,6-Diisopropyl-phenyl)-5-hydroxy-isoindole-1,3...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
University of Tokyo Curated by ChEMBL					Assay Description Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line				Bioorg Med Chem Lett 9: 559-62 (1999) BindingDB Entry DOI: 10.7270/Q2ZW1MFX
University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair