BDBM50075746 CHEMBL3415596

SMILES: Cc1cc(cc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(N)=O)n1)C(C)(C)O

InChI Key: InChIKey=GAKAFNUKJGXLLC-JKSUJKDBSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50075746   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50075746 (CHEMBL3415596) Show SMILES Cc1cc(cc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(N)=O)n1)C(C)(C)O |r| Show InChI InChI=1S/C21H30N6O2/c1-12-8-13(21(2,3)29)9-18(25-12)27-17-10-14(11-24-19(17)20(23)28)26-16-7-5-4-6-15(16)22/h8-11,15-16,26,29H,4-7,22H2,1-3H3,(H2,23,28)(H,25,27)/t15-,16+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co., Inc. Curated by ChEMBL					Assay Description Inhibition of ERG channel expressed in human embryonic kidney cells assessed as tail current amplitude measured for 3 to 30 mins by PatchXpress elect...				J Med Chem 58: 1929-39 (2015) Article DOI: 10.1021/jm5018169 BindingDB Entry DOI: 10.7270/Q2028T7D
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50075746 (CHEMBL3415596) Show SMILES Cc1cc(cc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(N)=O)n1)C(C)(C)O |r| Show InChI InChI=1S/C21H30N6O2/c1-12-8-13(21(2,3)29)9-18(25-12)27-17-10-14(11-24-19(17)20(23)28)26-16-7-5-4-6-15(16)22/h8-11,15-16,26,29H,4-7,22H2,1-3H3,(H2,23,28)(H,25,27)/t15-,16+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co., Inc. Curated by ChEMBL					Assay Description Inhibition of full-length GST-tagged human Syk preincubated for 10 mins followed by peptide substrate/ATP addition measured after 45 mins by TR-FRET ...				J Med Chem 58: 1929-39 (2015) Article DOI: 10.1021/jm5018169 BindingDB Entry DOI: 10.7270/Q2028T7D
					More data for this Ligand-Target Pair