BDBM50075856 (S)-2-({2'-Methyl-5-[((E)-2-pyridin-3-yl)-vinyl]-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid::CHEMBL349051

SMILES: CSCC[C@H](NC(=O)c1ccc(\C=C\c2cccnc2)cc1-c1ccccc1C)C(O)=O

InChI Key: InChIKey=PVPHNBNJQXLVQM-GTCGAKFVSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50075856   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50075856 ((S)-2-({2'-Methyl-5-[((E)-2-pyridin-3-yl)-vinyl]-b...) Show SMILES CSCC[C@H](NC(=O)c1ccc(\C=C\c2cccnc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C26H26N2O3S/c1-18-6-3-4-8-21(18)23-16-19(9-10-20-7-5-14-27-17-20)11-12-22(23)25(29)28-24(26(30)31)13-15-32-2/h3-12,14,16-17,24H,13,15H2,1-2H3,(H,28,29)(H,30,31)/b10-9+/t24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.610	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase (FT) using SPA assay				Bioorg Med Chem Lett 9: 703-8 (1999) BindingDB Entry DOI: 10.7270/Q2G73CWQ
					More data for this Ligand-Target Pair