BDBM50076644 CHEMBL175150::N-{1-ethyl-3-[1-(4-methoxyphenyl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]prop-2-ynyl}-N-hydroxyurea

SMILES: CCC(C#Cc1cc(-c2ccc(C)cc2)n(n1)-c1ccc(OC)cc1)N(O)C(N)=O

InChI Key: InChIKey=IZWFCWFUHBKUSC-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50076644   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50076644 (CHEMBL175150 | N-{1-ethyl-3-[1-(4-methoxyphenyl)-5...) Show SMILES CCC(C#Cc1cc(-c2ccc(C)cc2)n(n1)-c1ccc(OC)cc1)N(O)C(N)=O Show InChI InChI=1S/C23H24N4O3/c1-4-19(27(29)23(24)28)10-9-18-15-22(17-7-5-16(2)6-8-17)26(25-18)20-11-13-21(30-3)14-12-20/h5-8,11-15,19,29H,4H2,1-3H3,(H2,24,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
The R.W. Johnson Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibitory activity against 5-lipoxygenase(5-LO) using broken rat barophilic leukemia cells (RBL-1)				Bioorg Med Chem Lett 9: 979-84 (1999) BindingDB Entry DOI: 10.7270/Q2Z31XV3
					More data for this Ligand-Target Pair
Cyclooxygenase (RAT)	BDBM50076644 (CHEMBL175150 | N-{1-ethyl-3-[1-(4-methoxyphenyl)-5...) Show SMILES CCC(C#Cc1cc(-c2ccc(C)cc2)n(n1)-c1ccc(OC)cc1)N(O)C(N)=O Show InChI InChI=1S/C23H24N4O3/c1-4-19(27(29)23(24)28)10-9-18-15-22(17-7-5-16(2)6-8-17)26(25-18)20-11-13-21(30-3)14-12-20/h5-8,11-15,19,29H,4H2,1-3H3,(H2,24,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.59E+4	n/a	n/a	n/a	n/a	n/a	n/a
The R.W. Johnson Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibitory activity against Cyclooxygenase (COX) using broken rat barophilic leukemia cells (RBL-1)				Bioorg Med Chem Lett 9: 979-84 (1999) BindingDB Entry DOI: 10.7270/Q2Z31XV3
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50076644 (CHEMBL175150 | N-{1-ethyl-3-[1-(4-methoxyphenyl)-5...) Show SMILES CCC(C#Cc1cc(-c2ccc(C)cc2)n(n1)-c1ccc(OC)cc1)N(O)C(N)=O Show InChI InChI=1S/C23H24N4O3/c1-4-19(27(29)23(24)28)10-9-18-15-22(17-7-5-16(2)6-8-17)26(25-18)20-11-13-21(30-3)14-12-20/h5-8,11-15,19,29H,4H2,1-3H3,(H2,24,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.13E+4	n/a	n/a	n/a	n/a	n/a	n/a
The R.W. Johnson Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibitory activity against 5-lipoxygenase(5-LO) using broken rat barophilic leukemia cells (RBL-1)				Bioorg Med Chem Lett 9: 979-84 (1999) BindingDB Entry DOI: 10.7270/Q2Z31XV3
					More data for this Ligand-Target Pair
Cyclooxygenase (RAT)	BDBM50076644 (CHEMBL175150 | N-{1-ethyl-3-[1-(4-methoxyphenyl)-5...) Show SMILES CCC(C#Cc1cc(-c2ccc(C)cc2)n(n1)-c1ccc(OC)cc1)N(O)C(N)=O Show InChI InChI=1S/C23H24N4O3/c1-4-19(27(29)23(24)28)10-9-18-15-22(17-7-5-16(2)6-8-17)26(25-18)20-11-13-21(30-3)14-12-20/h5-8,11-15,19,29H,4H2,1-3H3,(H2,24,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
The R.W. Johnson Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibitory activity against 5-lipoxygenase (5-LO) in intact rat barophilic leukemia cells (RBL-1)				Bioorg Med Chem Lett 9: 979-84 (1999) BindingDB Entry DOI: 10.7270/Q2Z31XV3
					More data for this Ligand-Target Pair