BDBM50076900 3-(2-Bromo-4-isopropyl-phenyl)-7-diethylamino-5-methyl-3H-thiazolo[4,5-d]pyrimidin-2-one::CHEMBL278895

SMILES: CCN(CC)c1nc(C)nc2n(-c3ccc(cc3Br)C(C)C)c(=O)sc12

InChI Key: InChIKey=XSFIRVNENJWCEX-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50076900   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50076900 (3-(2-Bromo-4-isopropyl-phenyl)-7-diethylamino-5-me...) Show SMILES CCN(CC)c1nc(C)nc2n(-c3ccc(cc3Br)C(C)C)c(=O)sc12 |(12.56,-9.82,;12.57,-11.35,;13.88,-12.12,;15.23,-11.35,;15.23,-9.8,;13.91,-13.66,;12.57,-14.45,;12.57,-15.97,;11.25,-16.74,;13.91,-16.74,;15.25,-15.97,;16.7,-16.44,;17.18,-17.89,;16.16,-19.04,;16.64,-20.51,;18.17,-20.8,;19.19,-19.65,;18.69,-18.2,;19.78,-17.11,;18.65,-22.27,;17.62,-23.42,;20.15,-22.59,;17.62,-15.19,;19.16,-15.19,;16.7,-13.95,;15.23,-14.43,)| Show InChI InChI=1S/C19H23BrN4OS/c1-6-23(7-2)17-16-18(22-12(5)21-17)24(19(25)26-16)15-9-8-13(11(3)4)10-14(15)20/h8-11H,6-7H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	9.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Compound was tested for the binding affinity to human corticotropin releasing factor 1 (hCRF1) receptors				J Med Chem 43: 1641-60 (2000) BindingDB Entry DOI: 10.7270/Q29S1RRP
					More data for this Ligand-Target Pair
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50076900 (3-(2-Bromo-4-isopropyl-phenyl)-7-diethylamino-5-me...) Show SMILES CCN(CC)c1nc(C)nc2n(-c3ccc(cc3Br)C(C)C)c(=O)sc12 |(12.56,-9.82,;12.57,-11.35,;13.88,-12.12,;15.23,-11.35,;15.23,-9.8,;13.91,-13.66,;12.57,-14.45,;12.57,-15.97,;11.25,-16.74,;13.91,-16.74,;15.25,-15.97,;16.7,-16.44,;17.18,-17.89,;16.16,-19.04,;16.64,-20.51,;18.17,-20.8,;19.19,-19.65,;18.69,-18.2,;19.78,-17.11,;18.65,-22.27,;17.62,-23.42,;20.15,-22.59,;17.62,-15.19,;19.16,-15.19,;16.7,-13.95,;15.23,-14.43,)| Show InChI InChI=1S/C19H23BrN4OS/c1-6-23(7-2)17-16-18(22-12(5)21-17)24(19(25)26-16)15-9-8-13(11(3)4)10-14(15)20/h8-11H,6-7H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	9.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
DuPont Pharmaceuticals Company Curated by ChEMBL					Assay Description Binding affinity against human Corticotropin releasing factor receptor 1 expressed in HEK 293E cells using [125I]-TYR-oCRH				Bioorg Med Chem Lett 9: 1185-8 (1999) BindingDB Entry DOI: 10.7270/Q24M93Q4
					More data for this Ligand-Target Pair