BindingDB PrimarySearch

BDBM50077360 3,10-Dihydroxy-13-(3-hydroxy-4-methoxy-phenyl)-2,11-dimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one::CHEMBL301226

SMILES: COc1ccc(cc1O)-c1c2c(n3ccc4cc(O)c(OC)cc4c13)c(=O)oc1cc(O)c(OC)cc21

InChI Key: InChIKey=POCZBHBFCIWCCV-UHFFFAOYSA-N

Data: 7 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50077360
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50077360 (3,10-Dihydroxy-13-(3-hydroxy-4-methoxy-phenyl)-2,1...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Chemical Technology Curated by ChEMBL					Assay Description The compound was tested in vitro for inhibition of HIV-1 replication				J Med Chem 42: 1901-7 (1999) Article DOI: 10.1021/jm9806650 BindingDB Entry DOI: 10.7270/Q2PG1QWC
Institute of Chemical Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50077360 (3,10-Dihydroxy-13-(3-hydroxy-4-methoxy-phenyl)-2,1...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Chemical Technology Curated by ChEMBL					Assay Description Inhibitory activity agaginst integrase as yield of terminal cleavage products				J Med Chem 42: 1901-7 (1999) Article DOI: 10.1021/jm9806650 BindingDB Entry DOI: 10.7270/Q2PG1QWC
Institute of Chemical Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5) (Homo sapiens (Human))	BDBM50077360 (3,10-Dihydroxy-13-(3-hydroxy-4-methoxy-phenyl)-2,1...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Nagasaki University Curated by ChEMBL					Assay Description Inhibition of recombinant CDK5/p25 (unknown origin) expressed in Escherichia coli using [gamma-33P]ATP after 30 mins				J Med Chem 56: 7289-301 (2013) Article DOI: 10.1021/jm400719y BindingDB Entry DOI: 10.7270/Q2W37XQZ
Nagasaki University Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50077360 (3,10-Dihydroxy-13-(3-hydroxy-4-methoxy-phenyl)-2,1...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Nagasaki University Curated by ChEMBL					Assay Description Inhibition of recombinant EGFR (unknown origin) T790M/L858R double mutant preincubated for 30 mins followed by poly (Glu-Tyr) biotinylated peptide su...				Bioorg Med Chem 25: 6563-6580 (2017) Article DOI: 10.1016/j.bmc.2017.10.030 BindingDB Entry DOI: 10.7270/Q2RB7764
Nagasaki University Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50077360 (3,10-Dihydroxy-13-(3-hydroxy-4-methoxy-phenyl)-2,1...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Nagasaki University Curated by ChEMBL					Assay Description Inhibition of PIM1 (unknown origin) expressed in Escherichia coli using [gamma-33P]ATP after 30 mins				J Med Chem 56: 7289-301 (2013) Article DOI: 10.1021/jm400719y BindingDB Entry DOI: 10.7270/Q2W37XQZ
Nagasaki University Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50077360 (3,10-Dihydroxy-13-(3-hydroxy-4-methoxy-phenyl)-2,1...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Nagasaki University Curated by ChEMBL					Assay Description Inhibition of recombinant wild type EGFR (696 to C-terminal residues) (unknown origin) preincubated for 30 mins followed by poly (Glu-Tyr) biotinylat...				Bioorg Med Chem 25: 6563-6580 (2017) Article DOI: 10.1016/j.bmc.2017.10.030 BindingDB Entry DOI: 10.7270/Q2RB7764
Nagasaki University Curated by ChEMBL					More data for this Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A (Homo sapiens (Human))	BDBM50077360 (3,10-Dihydroxy-13-(3-hydroxy-4-methoxy-phenyl)-2,1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Nagasaki University Curated by ChEMBL					Assay Description Inhibition of human recombinant DYRK1A expressed in Escherichia coli using [gamma-33P]ATP after 30 mins				J Med Chem 56: 7289-301 (2013) Article DOI: 10.1021/jm400719y BindingDB Entry DOI: 10.7270/Q2W37XQZ
Nagasaki University Curated by ChEMBL					More data for this Ligand-Target Pair