BDBM50078381 CHEMBL3414918

SMILES: COc1cnc2ccc(cc2c1)[C@@](C)(F)c1nnc2c(F)cc(cn12)-c1cc(C)no1

InChI Key: InChIKey=WIXYFSZDBHGKBE-JOCHJYFZSA-N

Data: 2 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50078381   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50078381 (CHEMBL3414918) Show SMILES COc1cnc2ccc(cc2c1)[C@@](C)(F)c1nnc2c(F)cc(cn12)-c1cc(C)no1 |r| Show InChI InChI=1S/C22H17F2N5O2/c1-12-6-19(31-28-12)14-9-17(23)20-26-27-21(29(20)11-14)22(2,24)15-4-5-18-13(7-15)8-16(30-3)10-25-18/h4-11H,1-3H3/t22-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant c-Met kinase domain (unknown origin) incubated for 30 mins using gastrin peptide substrate by HTRF assay				J Med Chem 58: 2417-30 (2015) Article DOI: 10.1021/jm501913a BindingDB Entry DOI: 10.7270/Q2MP5502
					More data for this Ligand-Target Pair				3D Structure (crystal)
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50078381 (CHEMBL3414918) Show SMILES COc1cnc2ccc(cc2c1)[C@@](C)(F)c1nnc2c(F)cc(cn12)-c1cc(C)no1 |r| Show InChI InChI=1S/C22H17F2N5O2/c1-12-6-19(31-28-12)14-9-17(23)20-26-27-21(29(20)11-14)22(2,24)15-4-5-18-13(7-15)8-16(30-3)10-25-18/h4-11H,1-3H3/t22-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of HGF-stimulated c-Met autophosphorylation in serum starved human PC3 cells pre-incubated for 1 hr followed by human recombinant HGF stim...				J Med Chem 58: 2417-30 (2015) Article DOI: 10.1021/jm501913a BindingDB Entry DOI: 10.7270/Q2MP5502
					More data for this Ligand-Target Pair				3D Structure (crystal)