BDBM50078393 (S)-1-[(S)-1-((2S,3R)-3-Amino-2-hydroxy-4-phenyl-butyryl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carboxylic acid {(S)-1-[(S)-1-((R)-1-carbamoyl-2-mercapto-ethylcarbamoyl)-ethylcarbamoyl]-ethyl}-amide::CHEMBL78505

SMILES: C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](CS)C(N)=O

InChI Key: InChIKey=NZQDJXSJXCVXAN-FCZNNESMSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50078393   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Xaa-Pro aminopeptidase 2 (Rattus norvegicus)	BDBM50078393 ((S)-1-[(S)-1-((2S,3R)-3-Amino-2-hydroxy-4-phenyl-b...) Show SMILES C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](CS)C(N)=O Show InChI InChI=1S/C29H43N7O7S/c1-16(25(39)32-17(2)26(40)34-20(15-44)24(31)38)33-27(41)21-10-6-12-35(21)28(42)22-11-7-13-36(22)29(43)23(37)19(30)14-18-8-4-3-5-9-18/h3-5,8-9,16-17,19-23,37,44H,6-7,10-15,30H2,1-2H3,(H2,31,38)(H,32,39)(H,33,41)(H,34,40)/t16-,17-,19+,20-,21-,22-,23-/m0/s1	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	660	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia and Upjohn Curated by ChEMBL					Assay Description Activity against membrane bound rat aminopeptidase P				J Med Chem 42: 2394-402 (1999) Article DOI: 10.1021/jm9805642 BindingDB Entry DOI: 10.7270/Q2N878ZS
					More data for this Ligand-Target Pair
Membrane-bound aminopeptidase P (APP2) (Homo sapiens (Human))	BDBM50078393 ((S)-1-[(S)-1-((2S,3R)-3-Amino-2-hydroxy-4-phenyl-b...) Show SMILES C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](CS)C(N)=O Show InChI InChI=1S/C29H43N7O7S/c1-16(25(39)32-17(2)26(40)34-20(15-44)24(31)38)33-27(41)21-10-6-12-35(21)28(42)22-11-7-13-36(22)29(43)23(37)19(30)14-18-8-4-3-5-9-18/h3-5,8-9,16-17,19-23,37,44H,6-7,10-15,30H2,1-2H3,(H2,31,38)(H,32,39)(H,33,41)(H,34,40)/t16-,17-,19+,20-,21-,22-,23-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia and Upjohn Curated by ChEMBL					Assay Description Inhibition against membrane bound human aminopeptidase P				J Med Chem 42: 2394-402 (1999) Article DOI: 10.1021/jm9805642 BindingDB Entry DOI: 10.7270/Q2N878ZS
					More data for this Ligand-Target Pair
Xaa-Pro dipeptidase (Homo sapiens (Human))	BDBM50078393 ((S)-1-[(S)-1-((2S,3R)-3-Amino-2-hydroxy-4-phenyl-b...) Show SMILES C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](CS)C(N)=O Show InChI InChI=1S/C29H43N7O7S/c1-16(25(39)32-17(2)26(40)34-20(15-44)24(31)38)33-27(41)21-10-6-12-35(21)28(42)22-11-7-13-36(22)29(43)23(37)19(30)14-18-8-4-3-5-9-18/h3-5,8-9,16-17,19-23,37,44H,6-7,10-15,30H2,1-2H3,(H2,31,38)(H,32,39)(H,33,41)(H,34,40)/t16-,17-,19+,20-,21-,22-,23-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+5	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia and Upjohn Curated by ChEMBL					Assay Description Inhibition against Prolidase from pig kidney.				J Med Chem 42: 2394-402 (1999) Article DOI: 10.1021/jm9805642 BindingDB Entry DOI: 10.7270/Q2N878ZS
					More data for this Ligand-Target Pair
Membrane-bound aminopeptidase P (APP2) (Homo sapiens (Human))	BDBM50078393 ((S)-1-[(S)-1-((2S,3R)-3-Amino-2-hydroxy-4-phenyl-b...) Show SMILES C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](CS)C(N)=O Show InChI InChI=1S/C29H43N7O7S/c1-16(25(39)32-17(2)26(40)34-20(15-44)24(31)38)33-27(41)21-10-6-12-35(21)28(42)22-11-7-13-36(22)29(43)23(37)19(30)14-18-8-4-3-5-9-18/h3-5,8-9,16-17,19-23,37,44H,6-7,10-15,30H2,1-2H3,(H2,31,38)(H,32,39)(H,33,41)(H,34,40)/t16-,17-,19+,20-,21-,22-,23-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia and Upjohn Curated by ChEMBL					Assay Description Inhibition against membrane bound monkey aminopeptidase P				J Med Chem 42: 2394-402 (1999) Article DOI: 10.1021/jm9805642 BindingDB Entry DOI: 10.7270/Q2N878ZS
					More data for this Ligand-Target Pair
Xaa-Pro aminopeptidase 1 (Homo sapiens (Human))	BDBM50078393 ((S)-1-[(S)-1-((2S,3R)-3-Amino-2-hydroxy-4-phenyl-b...) Show SMILES C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](CS)C(N)=O Show InChI InChI=1S/C29H43N7O7S/c1-16(25(39)32-17(2)26(40)34-20(15-44)24(31)38)33-27(41)21-10-6-12-35(21)28(42)22-11-7-13-36(22)29(43)23(37)19(30)14-18-8-4-3-5-9-18/h3-5,8-9,16-17,19-23,37,44H,6-7,10-15,30H2,1-2H3,(H2,31,38)(H,32,39)(H,33,41)(H,34,40)/t16-,17-,19+,20-,21-,22-,23-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia and Upjohn Curated by ChEMBL					Assay Description Inhibition against cytosolic Aminopeptidase P from human heart.				J Med Chem 42: 2394-402 (1999) Article DOI: 10.1021/jm9805642 BindingDB Entry DOI: 10.7270/Q2N878ZS
					More data for this Ligand-Target Pair
Leucine aminopeptidase (Homo sapiens (Human))	BDBM50078393 ((S)-1-[(S)-1-((2S,3R)-3-Amino-2-hydroxy-4-phenyl-b...) Show SMILES C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](CS)C(N)=O Show InChI InChI=1S/C29H43N7O7S/c1-16(25(39)32-17(2)26(40)34-20(15-44)24(31)38)33-27(41)21-10-6-12-35(21)28(42)22-11-7-13-36(22)29(43)23(37)19(30)14-18-8-4-3-5-9-18/h3-5,8-9,16-17,19-23,37,44H,6-7,10-15,30H2,1-2H3,(H2,31,38)(H,32,39)(H,33,41)(H,34,40)/t16-,17-,19+,20-,21-,22-,23-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia and Upjohn Curated by ChEMBL					Assay Description Inhibition against Leucyl aminopeptidase from pig kidney.				J Med Chem 42: 2394-402 (1999) Article DOI: 10.1021/jm9805642 BindingDB Entry DOI: 10.7270/Q2N878ZS
					More data for this Ligand-Target Pair
Xaa-Pro aminopeptidase 1 (Homo sapiens (Human))	BDBM50078393 ((S)-1-[(S)-1-((2S,3R)-3-Amino-2-hydroxy-4-phenyl-b...) Show SMILES C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](CS)C(N)=O Show InChI InChI=1S/C29H43N7O7S/c1-16(25(39)32-17(2)26(40)34-20(15-44)24(31)38)33-27(41)21-10-6-12-35(21)28(42)22-11-7-13-36(22)29(43)23(37)19(30)14-18-8-4-3-5-9-18/h3-5,8-9,16-17,19-23,37,44H,6-7,10-15,30H2,1-2H3,(H2,31,38)(H,32,39)(H,33,41)(H,34,40)/t16-,17-,19+,20-,21-,22-,23-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia and Upjohn Curated by ChEMBL					Assay Description Inhibition against Aminopeptidase P from human platelets.				J Med Chem 42: 2394-402 (1999) Article DOI: 10.1021/jm9805642 BindingDB Entry DOI: 10.7270/Q2N878ZS
					More data for this Ligand-Target Pair