BDBM50078454 2-Amino-7-pyridin-2-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(pyridin-2-ylmethyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL315260

SMILES: Nc1nc2c(Cc3ccccn3)c[nH]c2c(=O)[nH]1

InChI Key: InChIKey=MQHSZSQKICPGTQ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50078454   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50078454 (2-Amino-7-pyridin-2-ylmethyl-3,5-dihydro-pyrrolo[3...) Show SMILES Nc1nc2c(Cc3ccccn3)c[nH]c2c(=O)[nH]1 Show InChI InChI=1S/C12H11N5O/c13-12-16-9-7(5-8-3-1-2-4-14-8)6-15-10(9)11(18)17-12/h1-4,6,15H,5H2,(H3,13,16,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal da Bahia Curated by ChEMBL					Assay Description Inhibition of human purine nucleoside phosphorylase				Bioorg Med Chem 18: 1421-7 (2010) Article DOI: 10.1016/j.bmc.2010.01.022 BindingDB Entry DOI: 10.7270/Q2571C49
					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Bos taurus (bovine))	BDBM50078454 (2-Amino-7-pyridin-2-ylmethyl-3,5-dihydro-pyrrolo[3...) Show SMILES Nc1nc2c(Cc3ccccn3)c[nH]c2c(=O)[nH]1 Show InChI InChI=1S/C12H11N5O/c13-12-16-9-7(5-8-3-1-2-4-14-8)6-15-10(9)11(18)17-12/h1-4,6,15H,5H2,(H3,13,16,17,18)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	15.3	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Curated by ChEMBL					Assay Description Inhibitory activity against calf spleen purine nucleoside phosphorylase (PNP) using inosine as substrate at a concentration of 10 uM.				J Med Chem 42: 2422-31 (1999) Article DOI: 10.1021/jm990037y BindingDB Entry DOI: 10.7270/Q2CR5SKN
					More data for this Ligand-Target Pair