BDBM50078681 CHEMBL3415456

SMILES: ONC(=O)c1ccc(NC2CCN(C2=O)c2ccccc2Cl)cc1

InChI Key: InChIKey=UFWROTGTGBWIJQ-UHFFFAOYSA-N

Data: 3 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50078681   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50078681 (CHEMBL3415456) Show SMILES ONC(=O)c1ccc(NC2CCN(C2=O)c2ccccc2Cl)cc1 Show InChI InChI=1S/C17H16ClN3O3/c18-13-3-1-2-4-15(13)21-10-9-14(17(21)23)19-12-7-5-11(6-8-12)16(22)20-24/h1-8,14,19,24H,9-10H2,(H,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.18E+4	n/a	n/a	n/a	n/a	n/a	n/a
Roche Innovation Center Shanghai Curated by ChEMBL					Assay Description Inhibition of HDAC1 (unknown origin) using RHKK(Ac)AMC as substrate				J Med Chem 58: 2809-20 (2015) Article DOI: 10.1021/jm502011f BindingDB Entry DOI: 10.7270/Q2B56MF0
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50078681 (CHEMBL3415456) Show SMILES ONC(=O)c1ccc(NC2CCN(C2=O)c2ccccc2Cl)cc1 Show InChI InChI=1S/C17H16ClN3O3/c18-13-3-1-2-4-15(13)21-10-9-14(17(21)23)19-12-7-5-11(6-8-12)16(22)20-24/h1-8,14,19,24H,9-10H2,(H,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.70E+3	n/a	n/a	n/a	n/a
Roche Innovation Center Shanghai Curated by ChEMBL					Assay Description Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISA				J Med Chem 58: 2809-20 (2015) Article DOI: 10.1021/jm502011f BindingDB Entry DOI: 10.7270/Q2B56MF0
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Homo sapiens (Human))	BDBM50078681 (CHEMBL3415456) Show SMILES ONC(=O)c1ccc(NC2CCN(C2=O)c2ccccc2Cl)cc1 Show InChI InChI=1S/C17H16ClN3O3/c18-13-3-1-2-4-15(13)21-10-9-14(17(21)23)19-12-7-5-11(6-8-12)16(22)20-24/h1-8,14,19,24H,9-10H2,(H,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Roche Innovation Center Shanghai Curated by ChEMBL					Assay Description Inhibition of HDAC8 (unknown origin) using RHK(Ac)K(Ac)AMC as substrate				J Med Chem 58: 2809-20 (2015) Article DOI: 10.1021/jm502011f BindingDB Entry DOI: 10.7270/Q2B56MF0
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50078681 (CHEMBL3415456) Show SMILES ONC(=O)c1ccc(NC2CCN(C2=O)c2ccccc2Cl)cc1 Show InChI InChI=1S/C17H16ClN3O3/c18-13-3-1-2-4-15(13)21-10-9-14(17(21)23)19-12-7-5-11(6-8-12)16(22)20-24/h1-8,14,19,24H,9-10H2,(H,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
Roche Innovation Center Shanghai Curated by ChEMBL					Assay Description Inhibition of HDAC6 (unknown origin) using RHKK(Ac)AMC as substrate				J Med Chem 58: 2809-20 (2015) Article DOI: 10.1021/jm502011f BindingDB Entry DOI: 10.7270/Q2B56MF0
					More data for this Ligand-Target Pair