Found 5 hits for monomerid = 50078834 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50078834
(2-(pyridin-2-yl)-1H-benzo[d]imidazole | 2-pyridin-...)Show InChI InChI=1S/C12H9N3/c1-2-6-10-9(5-1)14-12(15-10)11-7-3-4-8-13-11/h1-8H,(H,14,15) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | 6.00E+4 | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Dissociation constant when binding to FK506 binding protein (FKBP). |
J Med Chem 42: 2498-503 (1999)
Article DOI: 10.1021/jm990073x BindingDB Entry DOI: 10.7270/Q2639NZB |
More data for this Ligand-Target Pair | |
Methionine Aminopeptidase (MAP)
(Escherichia coli (strain K12)) | BDBM50078834
(2-(pyridin-2-yl)-1H-benzo[d]imidazole | 2-pyridin-...)Show InChI InChI=1S/C12H9N3/c1-2-6-10-9(5-1)14-12(15-10)11-7-3-4-8-13-11/h1-8H,(H,14,15) | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 574 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description Inhibition of Co2+ loaded MetAP expressed in Escherichia coli |
J Med Chem 49: 511-22 (2006)
Article DOI: 10.1021/jm050476z BindingDB Entry DOI: 10.7270/Q2N58KXD |
More data for this Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM50078834
(2-(pyridin-2-yl)-1H-benzo[d]imidazole | 2-pyridin-...)Show InChI InChI=1S/C12H9N3/c1-2-6-10-9(5-1)14-12(15-10)11-7-3-4-8-13-11/h1-8H,(H,14,15) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.33E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Heidelberg
Curated by ChEMBL
| Assay Description Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 20: 4038-44 (2010)
Article DOI: 10.1016/j.bmcl.2010.05.093 BindingDB Entry DOI: 10.7270/Q2RF5W0K |
More data for this Ligand-Target Pair | |
Methionine Aminopeptidase Type 1 (MetAP1)
(Homo sapiens (Human)) | BDBM50078834
(2-(pyridin-2-yl)-1H-benzo[d]imidazole | 2-pyridin-...)Show InChI InChI=1S/C12H9N3/c1-2-6-10-9(5-1)14-12(15-10)11-7-3-4-8-13-11/h1-8H,(H,14,15) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.84E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Heidelberg
Curated by ChEMBL
| Assay Description Inhibition of human MetAP1 |
Bioorg Med Chem Lett 20: 4038-44 (2010)
Article DOI: 10.1016/j.bmcl.2010.05.093 BindingDB Entry DOI: 10.7270/Q2RF5W0K |
More data for this Ligand-Target Pair | |
Cytochrome P450 2B1
(Rattus norvegicus) | BDBM50078834
(2-(pyridin-2-yl)-1H-benzo[d]imidazole | 2-pyridin-...)Show InChI InChI=1S/C12H9N3/c1-2-6-10-9(5-1)14-12(15-10)11-7-3-4-8-13-11/h1-8H,(H,14,15) | PDB
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 6.46E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory potency to aminopyrine N-demethylase activity (P450) in hepatic microsomes from phenobarbitone-induced rats. |
J Med Chem 25: 887-92 (1982)
BindingDB Entry DOI: 10.7270/Q2VT1T8J |
More data for this Ligand-Target Pair | |