BDBM50079356 CHEMBL511201

SMILES: NC(=O)c1c(F)ccc(OCc2nc3cc(Cl)cnc3s2)c1F

InChI Key: InChIKey=INYJNSBDHOVLAH-UHFFFAOYSA-N

Data: 3 IC50  1 EC50

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50079356   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cell division protein FtsZ (Staphylococcus aureus)	BDBM50079356 (CHEMBL511201) Show SMILES NC(=O)c1c(F)ccc(OCc2nc3cc(Cl)cnc3s2)c1F Show InChI InChI=1S/C14H8ClF2N3O2S/c15-6-3-8-14(19-4-6)23-10(20-8)5-22-9-2-1-7(16)11(12(9)17)13(18)21/h1-4H,5H2,(H2,18,21)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of Staphylococcus aureus FtsZ GTPase activity				Eur J Med Chem 95: 1-15 (2015) Article DOI: 10.1016/j.ejmech.2015.03.026 BindingDB Entry DOI: 10.7270/Q2S75J14
					More data for this Ligand-Target Pair				3D Structure (crystal)
Cell division protein FtsZ (Staphylococcus aureus)	BDBM50079356 (CHEMBL511201) Show SMILES NC(=O)c1c(F)ccc(OCc2nc3cc(Cl)cnc3s2)c1F Show InChI InChI=1S/C14H8ClF2N3O2S/c15-6-3-8-14(19-4-6)23-10(20-8)5-22-9-2-1-7(16)11(12(9)17)13(18)21/h1-4H,5H2,(H2,18,21)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Prolysis Curated by ChEMBL					Assay Description Inhibition of Staphylococcus aureus FtsZ GTPase activity				Science 321: 1673-5 (2008) Article DOI: 10.1126/science.1159961 BindingDB Entry DOI: 10.7270/Q2HX1GG1
					More data for this Ligand-Target Pair				3D Structure (crystal)
Cell division protein FtsZ (Staphylococcus aureus)	BDBM50079356 (CHEMBL511201) Show SMILES NC(=O)c1c(F)ccc(OCc2nc3cc(Cl)cnc3s2)c1F Show InChI InChI=1S/C14H8ClF2N3O2S/c15-6-3-8-14(19-4-6)23-10(20-8)5-22-9-2-1-7(16)11(12(9)17)13(18)21/h1-4H,5H2,(H2,18,21)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Stony Brook University Curated by ChEMBL					Assay Description Inhibition of Staphylococcus aureus FtsZ GTPase activity				Bioorg Med Chem 24: 6354-6369 (2016) Article DOI: 10.1016/j.bmc.2016.05.003 BindingDB Entry DOI: 10.7270/Q2SN0BZ0
					More data for this Ligand-Target Pair				3D Structure (crystal)
Cell division protein FtsZ (Staphylococcus aureus)	BDBM50079356 (CHEMBL511201) Show SMILES NC(=O)c1c(F)ccc(OCc2nc3cc(Cl)cnc3s2)c1F Show InChI InChI=1S/C14H8ClF2N3O2S/c15-6-3-8-14(19-4-6)23-10(20-8)5-22-9-2-1-7(16)11(12(9)17)13(18)21/h1-4H,5H2,(H2,18,21)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a
University of California at Davis Curated by ChEMBL					Assay Description Activation of Staphylococcus aureus FtsZ GTPase activity				ACS Med Chem Lett 6: 308-12 (2015) Article DOI: 10.1021/ml500497s BindingDB Entry DOI: 10.7270/Q2PV6N4C
					More data for this Ligand-Target Pair				3D Structure (crystal)