BDBM50079387 1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperidin-1-yl]-ethanol::CHEMBL28564::Eliprodil
SMILES: OC(CN1CCC(Cc2ccc(F)cc2)CC1)c1ccc(Cl)cc1
InChI Key: InChIKey=GGUSQTSTQSHJAH-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human)) | BDBM50079387 (1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Westf£lische Wilhelms-Universit£t M£nster Curated by ChEMBL | Assay Description Displacement of [3H]ifenprodil from human recombinant GluN2B expressed in mouse L(tk-) cell membranes co-expressing GluN1a incubated for 120 mins by ... | Bioorg Med Chem 28: (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human)) | BDBM50079387 (1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster Curated by ChEMBL | Assay Description Displacement of [3H]ifenprodil from human GluN2B expressed in mouse L(tk-) cell membranes co-expressing GluN1a incubated for 120 mins by scintillatio... | Bioorg Med Chem 27: 3559-3567 (2019) Article DOI: 10.1016/j.bmc.2019.06.035 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human)) | BDBM50079387 (1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Munster Curated by ChEMBL | Assay Description Displacement of [3H]ifenprodil from Glun2B receptor (unknown origin) expressed in mouse L(tk-) cell membranes after 120 mins by scintillation countin... | Bioorg Med Chem Lett 25: 5748-51 (2015) Article DOI: 10.1016/j.bmcl.2015.10.076 BindingDB Entry DOI: 10.7270/Q2639SQV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human)) | BDBM50079387 (1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster Curated by ChEMBL | Assay Description Displacement of [3H]Ifenprodil from GluN2B receptor (unknown origin) expressed in mouse L(tk-) cell membranes incubated for 120 mins measured for 5 m... | Eur J Med Chem 144: 672-681 (2018) Article DOI: 10.1016/j.ejmech.2017.12.054 BindingDB Entry DOI: 10.7270/Q2B56NDZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human)) | BDBM50079387 (1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GluN1/GluN2B NMDA receptor (Homo sapiens (Human)) | BDBM50079387 (1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut für Pharmazeutische und Medizinische Chemie der Westfälischen Wilhelms-Universität Münster Curated by ChEMBL | Assay Description Displacement of [3H]ifenprodil from human recombinant NR1-1a/NR2B receptor expressed in mouse L(tk-) cells after 120 mins by scintillation counting | Bioorg Med Chem 18: 8005-15 (2010) Article DOI: 10.1016/j.bmc.2010.09.026 BindingDB Entry DOI: 10.7270/Q28W3DJB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human)) | BDBM50079387 (1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster Curated by ChEMBL | Assay Description Displacement of [3H]ifenprodil from recombinant human GluN2B expressed in mouse L(tk-) cell membranes incubated for 120 mins by microbeta scintillati... | Eur J Med Chem 116: 136-146 (2016) BindingDB Entry DOI: 10.7270/Q261126Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human)) | BDBM50079387 (1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster Curated by ChEMBL | Assay Description Displacement of [3H]ifenprodil from human GluN2B expressed in mouse L(tk-) cells co-expressing GluN1a after 120 mins by scintillation counting method | Bioorg Med Chem 22: 6638-46 (2015) Article DOI: 10.1016/j.bmc.2014.10.004 BindingDB Entry DOI: 10.7270/Q2ZW1NH7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, NMDA 1 (RAT) | BDBM50079387 (1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd. Curated by PDSP Ki Database | J Neurochem 70: 2147-55 (1998) Article DOI: 10.1046/j.1471-4159.1998.70052147.x BindingDB Entry DOI: 10.7270/Q2KP80Q7 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50079387 (1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Tested for the Alpha-1 adrenergic receptor affinity in a standard radioligand binding assay with [3H]- prazosin | Bioorg Med Chem Lett 3: 91-94 (1993) Article DOI: 10.1016/S0960-894X(00)80098-0 BindingDB Entry DOI: 10.7270/Q2GT5N4S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NMDA receptor subunit 2C (GluN2C) (Rattus norvegicus (Rat)) | BDBM50079387 (1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Tested for the NMDA antagonist activity using a functional assay, by protection of cultured hippocampus neurons from the toxic effects of extracellul... | Bioorg Med Chem Lett 3: 91-94 (1993) Article DOI: 10.1016/S0960-894X(00)80098-0 BindingDB Entry DOI: 10.7270/Q2GT5N4S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate [NMDA] receptor subunit epsilon 2/zeta 1 (Rattus norvegicus (Rat)-RAT) | BDBM50079387 (1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CoCensys, Inc. Curated by ChEMBL | Assay Description In vitro inhibitory concentration against NMDA responses at NR1A/2B receptors expressed in Xenopus oocytes | J Med Chem 42: 2993-3000 (1999) Article DOI: 10.1021/jm990246i BindingDB Entry DOI: 10.7270/Q2RX9B8W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1 (RAT-Rattus norvegicus (Rat)) | BDBM50079387 (1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
CoCensys, Inc. Curated by ChEMBL | Assay Description In vitro inhibitory concentration against NMDA responses at NR1A/2C receptors expressed in Xenopus oocytes | J Med Chem 42: 2993-3000 (1999) Article DOI: 10.1021/jm990246i BindingDB Entry DOI: 10.7270/Q2RX9B8W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1 (Rattus norvegicus (Rat)-RAT) | BDBM50079387 (1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
CoCensys, Inc. Curated by ChEMBL | Assay Description In vitro inhibitory concentration against NMDA responses at cloned NR1A/2A receptors expressed in Xenopus oocytes | J Med Chem 42: 2993-3000 (1999) Article DOI: 10.1021/jm990246i BindingDB Entry DOI: 10.7270/Q2RX9B8W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate (NMDA) receptor subunit zeta 1 (Sus scrofa) | BDBM50079387 (1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 277 | n/a | n/a | n/a | n/a | n/a | n/a |
Zentrum für Pharmaforschung Curated by ChEMBL | Assay Description Displacement of [3H]-ifendropil from binding site of N-methyl-D-aspartate glutamate receptor was evaluated employing synaptosomal fraction of porcine... | Bioorg Med Chem Lett 10: 1377-80 (2000) BindingDB Entry DOI: 10.7270/Q2Q52NVP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate (NMDA) receptor subunit zeta 1 (Sus scrofa) | BDBM50079387 (1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
Zentrum für Pharmaforschung Curated by ChEMBL | Assay Description Compound was tested for inhibition of [3H]-MK-801 binding to N-methyl-D-aspartate glutamate receptor at NR2B subunit in high affinity fraction of por... | Bioorg Med Chem Lett 10: 1377-80 (2000) BindingDB Entry DOI: 10.7270/Q2Q52NVP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate (NMDA) receptor subunit zeta 1 (Sus scrofa) | BDBM50079387 (1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperid...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.13E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Zentrum für Pharmaforschung Curated by ChEMBL | Assay Description Compound was tested for inhibition of [3H]-MK-801 binding to N-methyl-D-aspartate glutamate receptor lacking NR2B subunit in low affinity fraction of... | Bioorg Med Chem Lett 10: 1377-80 (2000) BindingDB Entry DOI: 10.7270/Q2Q52NVP | |||||||||||
More data for this Ligand-Target Pair |