BindingDB PrimarySearch

BDBM50079455 CHEMBL46486::TETRAMETHYLAMMONIUM::tetramethylammonium

SMILES: C[N+](C)(C)C

InChI Key: InChIKey=QEMXHQIAXOOASZ-UHFFFAOYSA-N

Data: 9 KI 4 IC50

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50079455
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Homo sapiens (Human))	BDBM50079455 (CHEMBL46486 \| TETRAMETHYLAMMONIUM \| tetramethylamm...) Show SMILES C[N+](C)(C)C Show InChI InChI=1S/C4H12N/c1-5(2,3)4/h1-4H3/q+1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Targacept Inc. Curated by ChEMBL					Assay Description Binding affinity at heteropentameric Nicotinic acetylcholine receptor alpha4-beta2 subtype using [3H]-bungarotoxin as radioligand				J Med Chem 42: 3066-74 (1999) Article DOI: 10.1021/jm990093z BindingDB Entry DOI: 10.7270/Q2445KNP
Targacept Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50079455 (CHEMBL46486 \| TETRAMETHYLAMMONIUM \| tetramethylamm...) Show SMILES C[N+](C)(C)C Show InChI InChI=1S/C4H12N/c1-5(2,3)4/h1-4H3/q+1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Targacept Inc. Curated by ChEMBL					Assay Description Binding affinity at homopentameric Nicotinic acetylcholine receptor alpha7 subtype using [3H]-S-(-)-nicotine as radioligand				J Med Chem 42: 3066-74 (1999) Article DOI: 10.1021/jm990093z BindingDB Entry DOI: 10.7270/Q2445KNP
Targacept Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-bungarotoxin (Bungarus multicinctus)	BDBM50079455 (CHEMBL46486 \| TETRAMETHYLAMMONIUM \| tetramethylamm...) Show SMILES C[N+](C)(C)C Show InChI InChI=1S/C4H12N/c1-5(2,3)4/h1-4H3/q+1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
McGill University Curated by PDSP K_i Database									J Neurochem 67: 145-54 (1996) Article DOI: 10.1046/j.1471-4159.1996.67010145.x BindingDB Entry DOI: 10.7270/Q2SX6BQW
McGill University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
High affinity choline transporter 1 (Mus musculus)	BDBM50079455 (CHEMBL46486 \| TETRAMETHYLAMMONIUM \| tetramethylamm...) Show SMILES C[N+](C)(C)C Show InChI InChI=1S/C4H12N/c1-5(2,3)4/h1-4H3/q+1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	3.01E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern Ohio Universities Colleges of Medicine and Pharmacy Curated by ChEMBL					Assay Description Inhibition of [3H]choline uptake at choline transporter 1 in mouse brain synaptosome				Bioorg Med Chem Lett 20: 4870-7 (2010) Article DOI: 10.1016/j.bmcl.2010.06.090 BindingDB Entry DOI: 10.7270/Q29C6XMQ
					More data for this Ligand-Target Pair
Solute carrier family 22 member 2 (Homo sapiens (Human))	BDBM50079455 (CHEMBL46486 \| TETRAMETHYLAMMONIUM \| tetramethylamm...) Show SMILES C[N+](C)(C)C Show InChI InChI=1S/C4H12N/c1-5(2,3)4/h1-4H3/q+1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.80E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Anatomisches Institut der Bayerischen Julius-Maximilians-Universit£t Curated by ChEMBL					Assay Description TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytes				DNA Cell Biol 16: 871-81 (1997) Article DOI: 10.1089/dna.1997.16.871 BindingDB Entry DOI: 10.7270/Q2R2148R
					More data for this Ligand-Target Pair
Solute carrier family 22 member 1 (RAT)	BDBM50079455 (CHEMBL46486 \| TETRAMETHYLAMMONIUM \| tetramethylamm...) Show SMILES C[N+](C)(C)C Show InChI InChI=1S/C4H12N/c1-5(2,3)4/h1-4H3/q+1	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	9.05E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description TP_TRANSPORTER: inhibition of MPP+ uptake in Xenopus laevis oocytes				J Pharmacol Exp Ther 292: 1146-52 (2000) BindingDB Entry DOI: 10.7270/Q2XS5WPJ
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Solute carrier family 22 member 1 (RAT)	BDBM50079455 (CHEMBL46486 \| TETRAMETHYLAMMONIUM \| tetramethylamm...) Show SMILES C[N+](C)(C)C Show InChI InChI=1S/C4H12N/c1-5(2,3)4/h1-4H3/q+1	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bayerische Julius-Maximilians-Universit£t Curated by ChEMBL					Assay Description TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytes				Nature 372: 549-552 (1994) Article DOI: 10.1038/372549a0 BindingDB Entry DOI: 10.7270/Q2B56M05
					More data for this Ligand-Target Pair
Solute carrier family 22 member 1 (Mus musculus)	BDBM50079455 (CHEMBL46486 \| TETRAMETHYLAMMONIUM \| tetramethylamm...) Show SMILES C[N+](C)(C)C Show InChI InChI=1S/C4H12N/c1-5(2,3)4/h1-4H3/q+1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	2.04E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description TP_TRANSPORTER: inhibition of MPP+ uptake in Xenopus laevis oocytes				J Pharmacol Exp Ther 292: 1146-52 (2000) BindingDB Entry DOI: 10.7270/Q2XS5WPJ
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Solute carrier family 22 member 1 (Homo sapiens (Human))	BDBM50079455 (CHEMBL46486 \| TETRAMETHYLAMMONIUM \| tetramethylamm...) Show SMILES C[N+](C)(C)C Show InChI InChI=1S/C4H12N/c1-5(2,3)4/h1-4H3/q+1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	1.24E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description TP_TRANSPORTER: inhibition of MPP+ uptake in Xenopus laevis oocytes				J Pharmacol Exp Ther 292: 1146-52 (2000) BindingDB Entry DOI: 10.7270/Q2XS5WPJ
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Solute carrier family 22 member 2 (RAT)	BDBM50079455 (CHEMBL46486 \| TETRAMETHYLAMMONIUM \| tetramethylamm...) Show SMILES C[N+](C)(C)C Show InChI InChI=1S/C4H12N/c1-5(2,3)4/h1-4H3/q+1	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	1.67E+6	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto University Hospital Curated by ChEMBL					Assay Description TP_TRANSPORTER: inhibition of TEA uptake (TEA: 50 uM) in OCT2-expressing MDCK cells				Pharm Res 18: 1528-34 (2001) BindingDB Entry DOI: 10.7270/Q28G8N0T
Kyoto University Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Solute carrier family 22 member 2 (Homo sapiens (Human))	BDBM50079455 (CHEMBL46486 \| TETRAMETHYLAMMONIUM \| tetramethylamm...) Show SMILES C[N+](C)(C)C Show InChI InChI=1S/C4H12N/c1-5(2,3)4/h1-4H3/q+1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 1 uM) in Xenopus laevis oocytes				Pharm Res 19: 1244-7 (2002) BindingDB Entry DOI: 10.7270/Q2T154ZH
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Solute carrier family 22 member 2 (RAT)	BDBM50079455 (CHEMBL46486 \| TETRAMETHYLAMMONIUM \| tetramethylamm...) Show SMILES C[N+](C)(C)C Show InChI InChI=1S/C4H12N/c1-5(2,3)4/h1-4H3/q+1	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	6.30E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Anatomy of the Bayerische Julius-Maximilians-Universit£t Curated by ChEMBL					Assay Description TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes				Am J Physiol Renal Physiol 281: 454-68 (2001) Article DOI: 10.1152/ajprenal.2001.281.3.F454 BindingDB Entry DOI: 10.7270/Q2BR8TF3
					More data for this Ligand-Target Pair
Solute carrier family 22 member 1 (RAT)	BDBM50079455 (CHEMBL46486 \| TETRAMETHYLAMMONIUM \| tetramethylamm...) Show SMILES C[N+](C)(C)C Show InChI InChI=1S/C4H12N/c1-5(2,3)4/h1-4H3/q+1	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	1.14E+6	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto University Hospital Curated by ChEMBL					Assay Description TP_TRANSPORTER: inhibition of TEA uptake (TEA: 50 uM) in OCT1-expressing MDCK cells				Pharm Res 18: 1528-34 (2001) BindingDB Entry DOI: 10.7270/Q28G8N0T
Kyoto University Hospital Curated by ChEMBL					More data for this Ligand-Target Pair