BDBM50079803 (S)-2-{[(2S,4S)-1-((E)-(2S,5R)-5-Amino-2-isopropyl-6-mercapto-hex-3-enoyl)-4-phenoxy-pyrrolidine-2-carbonyl]-amino}-4-methylsulfanyl-butyric acid with di( TFA)::CHEMBL305536
SMILES: CSCC[C@H](NC(=O)[C@@H]1C[C@@H](CN1C(=O)[C@H](\C=C\[C@@H](N)CS)C(C)C)Oc1ccccc1)C(O)=O
InChI Key: InChIKey=XGFQAKQIQDYMMY-GTQJKTJRSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Geranylgeranyl Transferase (GGTase-I) (Bos taurus (bovine)) | BDBM50079803 ((S)-2-{[(2S,4S)-1-((E)-(2S,5R)-5-Amino-2-isopropyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Research Institute Curated by ChEMBL | Assay Description In vitro inhibitory activity against Geranylgeranyl transferase in the geranylgeranylation of H-ras-CAIL protein | Bioorg Med Chem Lett 9: 2095-100 (1999) BindingDB Entry DOI: 10.7270/Q2Z038PQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Farnesyltransferase (PFT) (Bos taurus (bovine)) | BDBM50079803 ((S)-2-{[(2S,4S)-1-((E)-(2S,5R)-5-Amino-2-isopropyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Research Institute Curated by ChEMBL | Assay Description Inhibitory concentration was evaluated against Farnesyltransferase in the farnesylation of H-ras protein | Bioorg Med Chem Lett 9: 2095-100 (1999) BindingDB Entry DOI: 10.7270/Q2Z038PQ | |||||||||||
More data for this Ligand-Target Pair |