BDBM50079939 (7-Chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-[1-(2-methoxy-phenyl)-piperidin-4-ylmethyl]-amine::CHEMBL418854
SMILES: COc1ccccc1N1CCC(CNCC2COc3ccc(Cl)cc3O2)CC1
InChI Key: InChIKey=QHLRKDSRGUZHSH-UHFFFAOYSA-N
Data: 17 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50079939 ((7-Chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Knoll Pharmaceuticals Curated by ChEMBL | Assay Description The compound was tested for binding affinity against human Dopamine receptor D3 | J Med Chem 42: 3342-55 (1999) Article DOI: 10.1021/jm9910122 BindingDB Entry DOI: 10.7270/Q2WH2P6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50079939 ((7-Chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Knoll Pharmaceuticals Curated by ChEMBL | Assay Description The compound was tested for binding affinity against 5-hydroxytryptamine 1A receptor receptor | J Med Chem 42: 3342-55 (1999) Article DOI: 10.1021/jm9910122 BindingDB Entry DOI: 10.7270/Q2WH2P6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50079939 ((7-Chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 13.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Knoll Pharmaceuticals Curated by ChEMBL | Assay Description The compound was tested for binding affinity against human Dopamine receptor D2L | J Med Chem 42: 3342-55 (1999) Article DOI: 10.1021/jm9910122 BindingDB Entry DOI: 10.7270/Q2WH2P6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50079939 ((7-Chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Knoll Pharmaceuticals Curated by ChEMBL | Assay Description Binding affinity towards 5-hydroxytryptamine 1A receptor from rat brain using [3H]-8-OH-DPAT as radioligand | J Med Chem 42: 3342-55 (1999) Article DOI: 10.1021/jm9910122 BindingDB Entry DOI: 10.7270/Q2WH2P6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50079939 ((7-Chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Knoll Pharmaceuticals Curated by ChEMBL | Assay Description The compound was tested for binding affinity against 5-hydroxytryptamine 7 receptor | J Med Chem 42: 3342-55 (1999) Article DOI: 10.1021/jm9910122 BindingDB Entry DOI: 10.7270/Q2WH2P6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50079939 ((7-Chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 44 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Knoll Pharmaceuticals Curated by ChEMBL | Assay Description Binding affinity of the compound to the dopamine receptor D2L in rat brain membranes | J Med Chem 42: 3342-55 (1999) Article DOI: 10.1021/jm9910122 BindingDB Entry DOI: 10.7270/Q2WH2P6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50079939 ((7-Chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 58 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Knoll Pharmaceuticals Curated by ChEMBL | Assay Description The compound was tested for binding affinity against 5-hydroxytryptamine 2C receptor | J Med Chem 42: 3342-55 (1999) Article DOI: 10.1021/jm9910122 BindingDB Entry DOI: 10.7270/Q2WH2P6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50079939 ((7-Chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 70.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Knoll Pharmaceuticals Curated by ChEMBL | Assay Description The compound was tested for binding affinity against Dopamine receptor D4 | J Med Chem 42: 3342-55 (1999) Article DOI: 10.1021/jm9910122 BindingDB Entry DOI: 10.7270/Q2WH2P6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HTR6 (RAT) | BDBM50079939 ((7-Chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)...) | Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | >500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Knoll Pharmaceuticals Curated by ChEMBL | Assay Description The compound was tested for binding affinity against 5-hydroxytryptamine 6 receptor | J Med Chem 42: 3342-55 (1999) Article DOI: 10.1021/jm9910122 BindingDB Entry DOI: 10.7270/Q2WH2P6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2A adrenergic receptor (Rattus norvegicus (rat)) | BDBM50079939 ((7-Chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)...) | PDB Reactome pathway KEGG GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | >500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Knoll Pharmaceuticals Curated by ChEMBL | Assay Description The compound was tested for binding affinity against alpha-2D adrenergic receptor | J Med Chem 42: 3342-55 (1999) Article DOI: 10.1021/jm9910122 BindingDB Entry DOI: 10.7270/Q2WH2P6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat)) | BDBM50079939 ((7-Chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | >500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Knoll Pharmaceuticals Curated by ChEMBL | Assay Description The compound was tested for binding affinity against 5-hydroxytryptamine 2A receptor | J Med Chem 42: 3342-55 (1999) Article DOI: 10.1021/jm9910122 BindingDB Entry DOI: 10.7270/Q2WH2P6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 4 (5-HT4) receptor (Sus scrofa) | BDBM50079939 ((7-Chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Knoll Pharmaceuticals Curated by ChEMBL | Assay Description The compound was tested for binding affinity against 5-hydroxytryptamine 4 receptor | J Med Chem 42: 3342-55 (1999) Article DOI: 10.1021/jm9910122 BindingDB Entry DOI: 10.7270/Q2WH2P6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(1B) dopamine receptor (Homo sapiens (Human)) | BDBM50079939 ((7-Chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Knoll Pharmaceuticals Curated by ChEMBL | Assay Description The compound was tested for binding affinity against human Dopamine receptor D5 | J Med Chem 42: 3342-55 (1999) Article DOI: 10.1021/jm9910122 BindingDB Entry DOI: 10.7270/Q2WH2P6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM50079939 ((7-Chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Knoll Pharmaceuticals Curated by ChEMBL | Assay Description The compound was tested for binding affinity against 5-hydroxytryptamine 3 receptor | J Med Chem 42: 3342-55 (1999) Article DOI: 10.1021/jm9910122 BindingDB Entry DOI: 10.7270/Q2WH2P6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 1b (5-HT1b) receptor (Sus scrofa) | BDBM50079939 ((7-Chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)...) | Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Knoll Pharmaceuticals Curated by ChEMBL | Assay Description The compound was tested for binding affinity against 5-hydroxytryptamine 1B receptor | J Med Chem 42: 3342-55 (1999) Article DOI: 10.1021/jm9910122 BindingDB Entry DOI: 10.7270/Q2WH2P6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H1 receptor (RAT) | BDBM50079939 ((7-Chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Knoll Pharmaceuticals Curated by ChEMBL | Assay Description The compound was tested for binding affinity against H1 receptor | J Med Chem 42: 3342-55 (1999) Article DOI: 10.1021/jm9910122 BindingDB Entry DOI: 10.7270/Q2WH2P6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(1A) dopamine receptor (Homo sapiens (Human)) | BDBM50079939 ((7-Chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Knoll Pharmaceuticals Curated by ChEMBL | Assay Description The compound was tested for binding affinity against human Dopamine receptor D1 | J Med Chem 42: 3342-55 (1999) Article DOI: 10.1021/jm9910122 BindingDB Entry DOI: 10.7270/Q2WH2P6K | |||||||||||
More data for this Ligand-Target Pair |