BDBM50080528 3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide::4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione::CHEMBL123292::Cycloheximid::Zykloheximid::cid_6197::cycloheximide::med.21724, Compound Cycloheximide
SMILES: C[C@H]1C[C@H](C)C(=O)[C@@H](C1)[C@H](O)CC1CC(=O)NC(=O)C1
InChI Key: InChIKey=YPHMISFOHDHNIV-FSZOTQKASA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Peptidyl-prolyl cis-trans isomerase FKBP1A (Homo sapiens (Human)) | BDBM50080528 (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Max-Planck Research Unit Curated by ChEMBL | Assay Description Inhibition constant(Ki) for inhibition of PPIase activity of human FK506 binding protein 12 (Conc=14 nM) of FKBPsfamily | J Med Chem 42: 3615-22 (1999) Article DOI: 10.1021/jm991038t BindingDB Entry DOI: 10.7270/Q2DB8124 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
FK506 binding protein 4 (Homo sapiens (Human)) | BDBM50080528 (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 2.42E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Max-Planck Research Unit Curated by ChEMBL | Assay Description Inhibition constant(Ki) for inhibition of PPIase activity of rabbit FK506 binding protein 52 (Conc=52 nM) of FKBPsfamily | J Med Chem 42: 3615-22 (1999) Article DOI: 10.1021/jm991038t BindingDB Entry DOI: 10.7270/Q2DB8124 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
FK506 binding protein 14 (Homo sapiens (Human)) | BDBM50080528 (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 7.62E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Max-Planck Research Unit Curated by ChEMBL | Assay Description Inhibition constant(Ki) for inhibition of PPIase activity of Photobacterium sp. FK506 binding protein 22 (Conc=41 nM) of FKBPsfamily | J Med Chem 42: 3615-22 (1999) Article DOI: 10.1021/jm991038t BindingDB Entry DOI: 10.7270/Q2DB8124 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
FK506 binding protein 3 (Homo sapiens (Human)) | BDBM50080528 (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 1.24E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Max-Planck Research Unit Curated by ChEMBL | Assay Description Inhibition constant(Ki) for inhibition of PPIase activity of L. pneumophilia FK506 binding protein 25 (Conc=40 nM) of FKBPsfamily | J Med Chem 42: 3615-22 (1999) Article DOI: 10.1021/jm991038t BindingDB Entry DOI: 10.7270/Q2DB8124 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 2 (Homo sapiens (Human)) | BDBM50080528 (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 1.87E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Max-Planck Research Unit Curated by ChEMBL | Assay Description Inhibition constant(Ki) for inhibition of PPIase activity of E. coli parvulin (Conc=4 nM) of Parvulins sfamily | J Med Chem 42: 3615-22 (1999) Article DOI: 10.1021/jm991038t BindingDB Entry DOI: 10.7270/Q2DB8124 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Homo sapiens (Human)) | BDBM50080528 (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Max-Planck Research Unit Curated by ChEMBL | Assay Description Inhibition constant(Ki) for inhibition of PPIase activity of human Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Conc=4 nM) of Parvulins fa... | J Med Chem 42: 3615-22 (1999) Article DOI: 10.1021/jm991038t BindingDB Entry DOI: 10.7270/Q2DB8124 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha (Homo sapiens (Human)) | BDBM50080528 (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Mississippi Curated by ChEMBL | Assay Description Inhibition of hypoxia-induced HIF1 activation in human HeLa cells by luciferase reporter gene assay | J Nat Prod 68: 947-50 (2005) Article DOI: 10.1021/np050029m BindingDB Entry DOI: 10.7270/Q23J3GRV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic initiation factor 4A-I (Homo sapiens (Human)) | BDBM50080528 (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 226 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics Curated by ChEMBL | Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... | J Med Chem 63: 5879-5955 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic initiation factor 4A-I (Homo sapiens (Human)) | BDBM50080528 (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 101 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics Curated by ChEMBL | Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... | J Med Chem 63: 5879-5955 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic initiation factor 4A-I (Homo sapiens (Human)) | BDBM50080528 (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics Curated by ChEMBL | Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... | J Med Chem 63: 5879-5955 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3C-like proteinase (3CL-PRO) (Human SARS coronavirus (SARS-CoV) (Severe acute re...) | BDBM50080528 (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a |
University of Bonn | Assay Description This is a review article. | Med Res Rev (2020) Article DOI: 10.1002/med.21724 BindingDB Entry DOI: 10.7270/Q2JS9ST6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3C-like proteinase (MERS-CoV) | BDBM50080528 (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 189 | n/a | n/a | n/a | n/a |
University of Bonn | Assay Description This is a review article. | Med Res Rev (2020) Article DOI: 10.1002/med.21724 BindingDB Entry DOI: 10.7270/Q2JS9ST6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peptidyl-prolyl cis-trans isomerase FKBP1A (Homo sapiens (Human)) | BDBM50080528 (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Max-Planck Research Unit Curated by ChEMBL | Assay Description Compound was evaluated for its inhibitory effect on human FK506 binding protein 12 by means of protease-coupled PPIase assay | J Med Chem 42: 3615-22 (1999) Article DOI: 10.1021/jm991038t BindingDB Entry DOI: 10.7270/Q2DB8124 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha trans-inducing protein (VP16) (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...) | BDBM50080528 (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...) | MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | 8.54E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay | Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide... | PubChem Bioassay (2013) BindingDB Entry DOI: 10.7270/Q2GM85ZT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic initiation factor 4A-I (Homo sapiens (Human)) | BDBM50080528 (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 142 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics Curated by ChEMBL | Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... | J Med Chem 63: 5879-5955 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RPL19A (Saccharomyces cerevisiae) | BDBM50080528 (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB PCBioAssay | n/a | n/a | n/a | n/a | 644 | n/a | n/a | n/a | n/a |
NMMLSC Curated by PubChem BioAssay | Assay Description University of New Mexico Assay Overview: Assay Support: 1R03 MH086450-01 Project Title: Chemical Screen of TOR pathway GFP fusion proteins in S. ... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2JQ0ZGP | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
COUP transcription factor 2 isoform a (Homo sapiens (Human)) | BDBM50080528 (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | 1.32E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay | PubChem Bioassay (2013) BindingDB Entry DOI: 10.7270/Q21Z431S | ||||||||||||
More data for this Ligand-Target Pair |