BDBM50080821 (R)-2-((2R,6S)-1-Methyl-6-phenethyl-piperidin-2-yl)-1-phenyl-ethanol::8R-hydroxylobelane::CHEMBL125511
SMILES: CN1[C@H](CCc2ccccc2)CCC[C@@H]1C[C@@H](O)c1ccccc1
InChI Key: InChIKey=MUSFCRGEWKAWEE-BHDDXSALSA-N
Data: 5 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50080821 ((R)-2-((2R,6S)-1-Methyl-6-phenethyl-piperidin-2-yl...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description Inhibition of [3H]5-HT uptake at SERT in rat hippocampal synaptosomes | Bioorg Med Chem Lett 16: 5018-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.070 BindingDB Entry DOI: 10.7270/Q2513XTK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor (Rattus norvegicus (Rat)) | BDBM50080821 ((R)-2-((2R,6S)-1-Methyl-6-phenethyl-piperidin-2-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.21E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description Inhibition of [3H]MLA binding to alpha7 nAChR in rat brain membrane | Bioorg Med Chem Lett 16: 5018-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.070 BindingDB Entry DOI: 10.7270/Q2513XTK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50080821 ((R)-2-((2R,6S)-1-Methyl-6-phenethyl-piperidin-2-yl...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.88E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description Inhibition of [3H]DA uptake at DAT in rat striatal synaptosomes | Bioorg Med Chem Lett 16: 5018-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.070 BindingDB Entry DOI: 10.7270/Q2513XTK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vesicular monoamine transporter 2 (VMAT2) (Rattus norvegicus (Rat)) | BDBM50080821 ((R)-2-((2R,6S)-1-Methyl-6-phenethyl-piperidin-2-yl...) | UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description Inhibition of [3H]DTBZ binding to VMAT2 in rat synaptic vesicle membrane | Bioorg Med Chem Lett 16: 5018-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.070 BindingDB Entry DOI: 10.7270/Q2513XTK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit (Rattus norvegicus (Rat)) | BDBM50080821 ((R)-2-((2R,6S)-1-Methyl-6-phenethyl-piperidin-2-yl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.36E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description Inhibition of [3H]NIC binding to alpha4beta2 nAChR in rat brain membrane | Bioorg Med Chem Lett 16: 5018-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.070 BindingDB Entry DOI: 10.7270/Q2513XTK | |||||||||||
More data for this Ligand-Target Pair |