BDBM50081188 CHEMBL3421981

SMILES: c1cc2c(ccnc2[nH]1)-c1c[nH]c2cnccc12

InChI Key: InChIKey=OAAPSDVPLURZJC-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50081188   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50081188 (CHEMBL3421981) Show SMILES c1cc2c(ccnc2[nH]1)-c1c[nH]c2cnccc12 Show InChI InChI=1S/C14H10N4/c1-4-15-8-13-10(1)12(7-18-13)9-2-5-16-14-11(9)3-6-17-14/h1-8,18H,(H,16,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.99E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant N-terminal His6-tagged IGF-1R using fluorescence substrate after 80 mins by caliper off-chip incubation mobility shif...				J Med Chem 58: 2834-44 (2015) Article DOI: 10.1021/acs.jmedchem.5b00098 BindingDB Entry DOI: 10.7270/Q23B61VW
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50081188 (CHEMBL3421981) Show SMILES c1cc2c(ccnc2[nH]1)-c1c[nH]c2cnccc12 Show InChI InChI=1S/C14H10N4/c1-4-15-8-13-10(1)12(7-18-13)9-2-5-16-14-11(9)3-6-17-14/h1-8,18H,(H,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	314	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length C-terminal His6-tagged CDK2 expressed in baculovirus infected Sf21 insect cells using fluorescence substr...				J Med Chem 58: 2834-44 (2015) Article DOI: 10.1021/acs.jmedchem.5b00098 BindingDB Entry DOI: 10.7270/Q23B61VW
					More data for this Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B (Homo sapiens (Human))	BDBM50081188 (CHEMBL3421981) Show SMILES c1cc2c(ccnc2[nH]1)-c1c[nH]c2cnccc12 Show InChI InChI=1S/C14H10N4/c1-4-15-8-13-10(1)12(7-18-13)9-2-5-16-14-11(9)3-6-17-14/h1-8,18H,(H,16,17)	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of recombinant Dyrk1B (unknown origin) using FITC-Asp-His-Thr-Gly-Phe-Leu-Thr-Glu-Tyr-Val-Ala-Thr-Arg-NH2 as substrate after 60 mins				J Med Chem 58: 2834-44 (2015) Article DOI: 10.1021/acs.jmedchem.5b00098 BindingDB Entry DOI: 10.7270/Q23B61VW
					More data for this Ligand-Target Pair
Dual-specificity tyrosine-regulated kinases 1B (Homo sapiens (Human))	BDBM50081188 (CHEMBL3421981) Show SMILES c1cc2c(ccnc2[nH]1)-c1c[nH]c2cnccc12 Show InChI InChI=1S/C14H10N4/c1-4-15-8-13-10(1)12(7-18-13)9-2-5-16-14-11(9)3-6-17-14/h1-8,18H,(H,16,17)	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	378	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human full length C-terminal c-Myc tagged Dyrk1B phosphorylation overexpressed in monkey COS1 cells after 5 hrs by ELISA				J Med Chem 58: 2834-44 (2015) Article DOI: 10.1021/acs.jmedchem.5b00098 BindingDB Entry DOI: 10.7270/Q23B61VW
					More data for this Ligand-Target Pair