BDBM50081704 5-Methoxy-3-((R)-1-methyl-pyrrolidin-2-ylmethyl)-1H-indole::CHEMBL137485

SMILES: COc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1

InChI Key: InChIKey=MKEGUJPBCIXABO-GFCCVEGCSA-N

Data: 1 KI  6 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50081704   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50081704 (5-Methoxy-3-((R)-1-methyl-pyrrolidin-2-ylmethyl)-1...) Show SMILES COc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1 Show InChI InChI=1S/C15H20N2O/c1-17-7-3-4-12(17)8-11-10-16-15-6-5-13(18-2)9-14(11)15/h5-6,9-10,12,16H,3-4,7-8H2,1-2H3/t12-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Compound was tested for binding affinity using [3H]-MDL-100,907 at 5-hydroxytryptamine 2A receptor sites in rat cortical homogenate.				J Med Chem 42: 4257-63 (1999) BindingDB Entry DOI: 10.7270/Q2FX78PW
					More data for this Ligand-Target Pair
Serotonin 1d (5-HT1d) receptor (GUINEA PIG)	BDBM50081704 (5-Methoxy-3-((R)-1-methyl-pyrrolidin-2-ylmethyl)-1...) Show SMILES COc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1 Show InChI InChI=1S/C15H20N2O/c1-17-7-3-4-12(17)8-11-10-16-15-6-5-13(18-2)9-14(11)15/h5-6,9-10,12,16H,3-4,7-8H2,1-2H3/t12-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	43	n/a	n/a	n/a	n/a
Pfizer, Inc Curated by ChEMBL					Assay Description Effect of the compound on forskolin stimulated adenylate cyclase activity at 5-HT1D receptor of guinea pig substantia nigra.				J Med Chem 35: 4503-5 (1992) BindingDB Entry DOI: 10.7270/Q29C6WC5
					More data for this Ligand-Target Pair
Serotonin receptor 2a and 2c (5HT2A and 5HT2C) (Rattus norvegicus (Rat))	BDBM50081704 (5-Methoxy-3-((R)-1-methyl-pyrrolidin-2-ylmethyl)-1...) Show SMILES COc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1 Show InChI InChI=1S/C15H20N2O/c1-17-7-3-4-12(17)8-11-10-16-15-6-5-13(18-2)9-14(11)15/h5-6,9-10,12,16H,3-4,7-8H2,1-2H3/t12-/m1/s1	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc Curated by ChEMBL					Assay Description Binding affinity of the compound against 5-hydroxytryptamine 1C receptor				J Med Chem 35: 4503-5 (1992) BindingDB Entry DOI: 10.7270/Q29C6WC5
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50081704 (5-Methoxy-3-((R)-1-methyl-pyrrolidin-2-ylmethyl)-1...) Show SMILES COc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1 Show InChI InChI=1S/C15H20N2O/c1-17-7-3-4-12(17)8-11-10-16-15-6-5-13(18-2)9-14(11)15/h5-6,9-10,12,16H,3-4,7-8H2,1-2H3/t12-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	35	n/a	n/a	n/a	n/a
Pfizer, Inc Curated by ChEMBL					Assay Description Effect of the compound on forskolin stimulated adenylate cyclase activity at 5-hydroxytryptamine 1A receptor of guinea pig hippocampus.				J Med Chem 35: 4503-5 (1992) BindingDB Entry DOI: 10.7270/Q29C6WC5
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50081704 (5-Methoxy-3-((R)-1-methyl-pyrrolidin-2-ylmethyl)-1...) Show SMILES COc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1 Show InChI InChI=1S/C15H20N2O/c1-17-7-3-4-12(17)8-11-10-16-15-6-5-13(18-2)9-14(11)15/h5-6,9-10,12,16H,3-4,7-8H2,1-2H3/t12-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc Curated by ChEMBL					Assay Description Binding affinity against 5-hydroxytryptamine 1A receptor				J Med Chem 35: 4503-5 (1992) BindingDB Entry DOI: 10.7270/Q29C6WC5
					More data for this Ligand-Target Pair
Serotonin 2 (5-HT2) receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)	BDBM50081704 (5-Methoxy-3-((R)-1-methyl-pyrrolidin-2-ylmethyl)-1...) Show SMILES COc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1 Show InChI InChI=1S/C15H20N2O/c1-17-7-3-4-12(17)8-11-10-16-15-6-5-13(18-2)9-14(11)15/h5-6,9-10,12,16H,3-4,7-8H2,1-2H3/t12-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc Curated by ChEMBL					Assay Description Binding affinity against 5-hydroxytryptamine 2 receptor using [125I]DOI as radioligand.				J Med Chem 35: 4503-5 (1992) BindingDB Entry DOI: 10.7270/Q29C6WC5
					More data for this Ligand-Target Pair
Serotonin 2 (5-HT2) receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)	BDBM50081704 (5-Methoxy-3-((R)-1-methyl-pyrrolidin-2-ylmethyl)-1...) Show SMILES COc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1 Show InChI InChI=1S/C15H20N2O/c1-17-7-3-4-12(17)8-11-10-16-15-6-5-13(18-2)9-14(11)15/h5-6,9-10,12,16H,3-4,7-8H2,1-2H3/t12-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	730	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc Curated by ChEMBL					Assay Description Binding affinity against 5-hydroxytryptamine 2 receptor using [3H]ket as radioligand.				J Med Chem 35: 4503-5 (1992) BindingDB Entry DOI: 10.7270/Q29C6WC5
					More data for this Ligand-Target Pair
Serotonin 1d (5-HT1d) receptor (GUINEA PIG)	BDBM50081704 (5-Methoxy-3-((R)-1-methyl-pyrrolidin-2-ylmethyl)-1...) Show SMILES COc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1 Show InChI InChI=1S/C15H20N2O/c1-17-7-3-4-12(17)8-11-10-16-15-6-5-13(18-2)9-14(11)15/h5-6,9-10,12,16H,3-4,7-8H2,1-2H3/t12-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc Curated by ChEMBL					Assay Description Binding affinity against 5-hydroxytryptamine 1D receptor				J Med Chem 35: 4503-5 (1992) BindingDB Entry DOI: 10.7270/Q29C6WC5
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1B (Homo sapiens (Human))	BDBM50081704 (5-Methoxy-3-((R)-1-methyl-pyrrolidin-2-ylmethyl)-1...) Show SMILES COc1ccc2[nH]cc(C[C@H]3CCCN3C)c2c1 Show InChI InChI=1S/C15H20N2O/c1-17-7-3-4-12(17)8-11-10-16-15-6-5-13(18-2)9-14(11)15/h5-6,9-10,12,16H,3-4,7-8H2,1-2H3/t12-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	830	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc Curated by ChEMBL					Assay Description Binding affinity of the compound against 5-hydroxytryptamine 1B receptor				J Med Chem 35: 4503-5 (1992) BindingDB Entry DOI: 10.7270/Q29C6WC5
					More data for this Ligand-Target Pair