BDBM50082410 4-fluoro-7-[2-hydroxy-3-spiro[1,3-dihydrobenzo[e]isobenzofuran-3,4'-(hexahydropyridine)]-1-ylpropoxy]-1-indanone::CHEMBL111713
SMILES: OC(COc1ccc(F)c2CCC(=O)c12)CN1CCC2(CC1)OCc1c2ccc2ccccc12
InChI Key: InChIKey=ZAPJYPXIPRXXNB-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50082410 (4-fluoro-7-[2-hydroxy-3-spiro[1,3-dihydrobenzo[e]i...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Curated by ChEMBL | Assay Description Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cells | Bioorg Med Chem Lett 9: 3243-8 (1999) BindingDB Entry DOI: 10.7270/Q2W37WVB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50082410 (4-fluoro-7-[2-hydroxy-3-spiro[1,3-dihydrobenzo[e]i...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Curated by ChEMBL | Assay Description Displacement of specific [3H]- citalopram binding to 5-HT uptake site in rat whole cortex | Bioorg Med Chem Lett 9: 3243-8 (1999) BindingDB Entry DOI: 10.7270/Q2W37WVB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50082410 (4-fluoro-7-[2-hydroxy-3-spiro[1,3-dihydrobenzo[e]i...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a |
Merck Curated by ChEMBL | Assay Description Stimulation of [35S]- GIPyS binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cells | Bioorg Med Chem Lett 9: 3243-8 (1999) BindingDB Entry DOI: 10.7270/Q2W37WVB | |||||||||||
More data for this Ligand-Target Pair |