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BDBM50082902 2-[(5-{[Benzyl-(2-cyclohexyl-ethyl)-amino]-methyl}-2'-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-lithium-butarate::CHEMBL178430

SMILES: CSCC[C@H](NC(=O)c1ccc(CN(CCC2CCCCC2)Cc2ccccc2)cc1-c1ccccc1C)C([O-])=O

InChI Key: InChIKey=YSALBQMSZGKSOB-XIFFEERXSA-M

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50082902   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50082902
PNG
(2-[(5-{[Benzyl-(2-cyclohexyl-ethyl)-amino]-methyl}...)
Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(CCC2CCCCC2)Cc2ccccc2)cc1-c1ccccc1C)C([O-])=O
Show InChI InChI=1S/C35H44N2O3S/c1-26-11-9-10-16-30(26)32-23-29(17-18-31(32)34(38)36-33(35(39)40)20-22-41-2)25-37(24-28-14-7-4-8-15-28)21-19-27-12-5-3-6-13-27/h4,7-11,14-18,23,27,33H,3,5-6,12-13,19-22,24-25H2,1-2H3,(H,36,38)(H,39,40)/p-1/t33-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 3.5n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase)

J Med Chem 42: 4844-52 (1999)


BindingDB Entry DOI: 10.7270/Q2WW7GWR
More data for this
Ligand-Target Pair