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SMILES: CSCC[C@H](NC(=O)c1ccc(CN(CCC2CCCCC2)C(=O)c2ccccc2)cc1-c1ccccc1C)C([O-])=O

InChI Key: InChIKey=VRNRWEFFIHKNHV-YTTGMZPUSA-M

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50082903   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Rattus norvegicus-Rattus norvegicus (rat))		BDBM50082903
PNG
(2-[(5-{[Benzoyl-(2-cyclohexyl-ethyl)-amino]-methyl...)
Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(CCC2CCCCC2)C(=O)c2ccccc2)cc1-c1ccccc1C)C([O-])=O
Show InChI InChI=1S/C35H42N2O4S/c1-25-11-9-10-16-29(25)31-23-27(17-18-30(31)33(38)36-32(35(40)41)20-22-42-2)24-37(21-19-26-12-5-3-6-13-26)34(39)28-14-7-4-8-15-28/h4,7-11,14-18,23,26,32H,3,5-6,12-13,19-22,24H2,1-2H3,(H,36,38)(H,40,41)/p-1/t32-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.10n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Farnesyltransferase (FTase)

J Med Chem 42: 4844-52 (1999)


BindingDB Entry DOI: 10.7270/Q2WW7GWR
More data for this
Ligand-Target Pair