null
SMILES: OC(=O)[C@H](CNC(=O)C1=NOC(CCCCNc2ncc[nH]2)C1)NS(=O)(=O)c1ccccc1
InChI Key: InChIKey=VTKFSONVTHBFEO-JRZJBTRGSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50083768 ((S)3-({5-[4-(1H-Imidazol-2-ylamino)-butyl]-4,5-dih...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 930 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company Curated by ChEMBL | Assay Description Inhibition of platelet aggregation in human gel-purified platelets containing fibrinogen (GPP+Fg). | J Med Chem 43: 27-40 (2000) BindingDB Entry DOI: 10.7270/Q2571B77 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-3 (Homo sapiens (Human)) | BDBM50083768 ((S)3-({5-[4-(1H-Imidazol-2-ylamino)-butyl]-4,5-dih...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 10.6 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company Curated by ChEMBL | Assay Description Inhibition of vitronectin receptor (alpha V beta 3), expressed on human 293 cells, binding to immobilized fibrinogen | J Med Chem 43: 27-40 (2000) BindingDB Entry DOI: 10.7270/Q2571B77 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50083768 ((S)3-({5-[4-(1H-Imidazol-2-ylamino)-butyl]-4,5-dih...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 980 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company Curated by ChEMBL | Assay Description Inhibition of platelet aggregation in human platelet rich plasma (PRP) | J Med Chem 43: 27-40 (2000) BindingDB Entry DOI: 10.7270/Q2571B77 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50083768 ((S)3-({5-[4-(1H-Imidazol-2-ylamino)-butyl]-4,5-dih...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 890 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company Curated by ChEMBL | Assay Description Inhibition of platelet aggregation in human gel-purified platelets containing fibrinogen (GPP+Fg). | J Med Chem 43: 27-40 (2000) BindingDB Entry DOI: 10.7270/Q2571B77 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-V/beta-3 (Homo sapiens (Human)) | BDBM50083768 ((S)3-({5-[4-(1H-Imidazol-2-ylamino)-butyl]-4,5-dih...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 66 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company Curated by ChEMBL | Assay Description Inhibition of vitronectin receptor (alpha V beta 3), expressed on human 293 cells, binding to immobilized fibrinogen | J Med Chem 43: 27-40 (2000) BindingDB Entry DOI: 10.7270/Q2571B77 | |||||||||||
More data for this Ligand-Target Pair |