BDBM50084827 2,7-Dinitro-9-oxo-9H-fluorene-4-carboxylic acid N'-(2,4-dinitro-phenyl)-hydrazide::CHEMBL132497
SMILES: [O-][N+](=O)c1ccc-2c(c1)C(=O)c1cc(cc(C(=O)NNc3ccc(cc3[N+]([O-])=O)[N+]([O-])=O)c-21)[N+]([O-])=O
InChI Key: InChIKey=WOPGZCXUGQQZCP-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit (Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50084827 (2,7-Dinitro-9-oxo-9H-fluorene-4-carboxylic acid N'...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 1.10E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Medical School and Mayo Clinic Curated by ChEMBL | Assay Description In vitro inhibition of Farnesyltransferase (FT) by using FT [3H]-SPA kit. | J Med Chem 43: 401-8 (2000) BindingDB Entry DOI: 10.7270/Q28W3F0K | |||||||||||
More data for this Ligand-Target Pair |