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BDBM50084872 CHEMBL138155::[8-(2,4-Dichloro-phenyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl]-(1-methoxymethyl-propyl)-amine

SMILES: CCC(COC)Nc1nc(C)nc2c(c(C)nn12)-c1ccc(Cl)cc1Cl

InChI Key: InChIKey=MMQWCZIMBJFXSJ-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50084872   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50084872
PNG
(CHEMBL138155 | [8-(2,4-Dichloro-phenyl)-2,7-dimeth...)
Show SMILES CCC(COC)Nc1nc(C)nc2c(c(C)nn12)-c1ccc(Cl)cc1Cl |(7.35,1.18,;6.96,-.3,;5.47,-.72,;4.4,.37,;4.78,1.85,;3.67,2.94,;5.1,-2.22,;4.62,-3.67,;3.12,-4.02,;2.66,-5.47,;1.16,-5.82,;3.7,-6.59,;5.2,-6.27,;6.43,-7.17,;7.68,-6.27,;9.14,-6.75,;7.2,-4.79,;5.66,-4.82,;6.43,-8.71,;5.13,-9.48,;5.13,-11.02,;6.43,-11.79,;6.43,-13.33,;7.8,-11.02,;7.8,-9.48,;9.11,-8.71,)|
Show InChI InChI=1S/C18H21Cl2N5O/c1-5-13(9-26-4)23-18-22-11(3)21-17-16(10(2)24-25(17)18)14-7-6-12(19)8-15(14)20/h6-8,13H,5,9H2,1-4H3,(H,21,22,23)
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Similars
PubMed
 1.90n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Displacement of [125I]-tyrosine-ovine-CRF from human Corticotropin releasing factor receptor 1

J Med Chem 43: 449-56 (2000)


BindingDB Entry DOI: 10.7270/Q2542P9M
More data for this
Ligand-Target Pair