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BDBM50084873 CHEMBL336678::[8-(2,4-Dichloro-phenyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl]-(1-ethyl-propyl)-amine

SMILES: CCC(CC)Nc1nc(C)nc2c(c(C)nn12)-c1ccc(Cl)cc1Cl

InChI Key: InChIKey=KLPKJSFPRNBGKI-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50084873   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50084873
PNG
(CHEMBL336678 | [8-(2,4-Dichloro-phenyl)-2,7-dimeth...)
Show SMILES CCC(CC)Nc1nc(C)nc2c(c(C)nn12)-c1ccc(Cl)cc1Cl |(10.17,.44,;8.83,1.19,;7.5,.42,;6.27,1.35,;4.86,.77,;7.11,-1.07,;6.63,-2.54,;5.13,-2.87,;4.67,-4.34,;3.15,-4.68,;5.71,-5.47,;7.21,-5.15,;8.46,-6.05,;9.7,-5.15,;11.17,-5.61,;9.21,-3.67,;7.67,-3.68,;8.46,-7.59,;7.14,-8.37,;7.14,-9.91,;8.46,-10.68,;8.46,-12.23,;9.81,-9.91,;9.81,-8.37,;11.13,-7.57,)|
Show InChI InChI=1S/C18H21Cl2N5/c1-5-13(6-2)23-18-22-11(4)21-17-16(10(3)24-25(17)18)14-8-7-12(19)9-15(14)20/h7-9,13H,5-6H2,1-4H3,(H,21,22,23)
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Similars
PubMed
 1.10n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Displacement of [125I]-tyrosine-ovine-CRF from human Corticotropin releasing factor receptor 1

J Med Chem 43: 449-56 (2000)


BindingDB Entry DOI: 10.7270/Q2542P9M
More data for this
Ligand-Target Pair