BDBM50084893 (S)-3-(dibenzo[b,d]furan-3-yl)-2-(phosphonomethylamino)propanoic acid::3-Dibenzofuran-3-yl-2-(phosphonomethyl-amino)-propionic acid::CHEMBL146936
SMILES: OC(=O)[C@H](Cc1ccc2c(c1)oc1ccccc21)NCP(O)(O)=O
InChI Key: InChIKey=CRUVAUSVWLATAE-ZDUSSCGKSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Neprilysin (Homo sapiens (Human)) | BDBM50084893 ((S)-3-(dibenzo[b,d]furan-3-yl)-2-(phosphonomethyla...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CEA, DSV, Service d'Ingenierie Moleculaire des Proteines (SIMOPRO) Curated by ChEMBL | Assay Description Inhibition of human somatic NEP | J Med Chem 53: 208-20 (2010) Article DOI: 10.1021/jm9010803 BindingDB Entry DOI: 10.7270/Q2736R06 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-converting enzyme 1 (ECE1) (Homo sapiens (Human)) | BDBM50084893 ((S)-3-(dibenzo[b,d]furan-3-yl)-2-(phosphonomethyla...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute for Biomedical Research Curated by ChEMBL | Assay Description In Vitro inhibition of recombinant human endothelin converting enzyme-1 | J Med Chem 43: 488-504 (2000) BindingDB Entry DOI: 10.7270/Q21G0MZR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutral Endopeptidase (NEP) (Rattus norvegicus (Rat)) | BDBM50084893 ((S)-3-(dibenzo[b,d]furan-3-yl)-2-(phosphonomethyla...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institute for Biomedical Research Curated by ChEMBL | Assay Description In vitro inhibition of rat neutral endopeptidase | J Med Chem 43: 488-504 (2000) BindingDB Entry DOI: 10.7270/Q21G0MZR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-converting enzyme 1 (ECE1) (Homo sapiens (Human)) | BDBM50084893 ((S)-3-(dibenzo[b,d]furan-3-yl)-2-(phosphonomethyla...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
CEA, DSV, Service d'Ingenierie Moleculaire des Proteines (SIMOPRO) Curated by ChEMBL | Assay Description Inhibition of human somatic ECE1 | J Med Chem 53: 208-20 (2010) Article DOI: 10.1021/jm9010803 BindingDB Entry DOI: 10.7270/Q2736R06 | |||||||||||
More data for this Ligand-Target Pair |