BDBM50085134 (4-Methyl-piperazin-1-yl)-[8-(3-nitro-phenyl)-[1,7]naphthyridin-6-yl]-methanone::CHEMBL161602

SMILES: CN1CCN(CC1)C(=O)c1cc2cccnc2c(n1)-c1cccc(c1)[N+]([O-])=O

InChI Key: InChIKey=ODTOBENNZQIDCO-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50085134   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50085134 ((4-Methyl-piperazin-1-yl)-[8-(3-nitro-phenyl)-[1,7...) Show SMILES CN1CCN(CC1)C(=O)c1cc2cccnc2c(n1)-c1cccc(c1)[N+]([O-])=O Show InChI InChI=1S/C20H19N5O3/c1-23-8-10-24(11-9-23)20(26)17-13-15-5-3-7-21-18(15)19(22-17)14-4-2-6-16(12-14)25(27)28/h2-7,12-13H,8-11H2,1H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharma AG Curated by ChEMBL					Assay Description Inhibitory activity against Phosphodiesterase 4D (PDE4D) from human source expressed in Saccharomyces cerevisiae				J Med Chem 43: 675-82 (2000) BindingDB Entry DOI: 10.7270/Q2N58N3G
					More data for this Ligand-Target Pair
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50085134 ((4-Methyl-piperazin-1-yl)-[8-(3-nitro-phenyl)-[1,7...) Show SMILES CN1CCN(CC1)C(=O)c1cc2cccnc2c(n1)-c1cccc(c1)[N+]([O-])=O Show InChI InChI=1S/C20H19N5O3/c1-23-8-10-24(11-9-23)20(26)17-13-15-5-3-7-21-18(15)19(22-17)14-4-2-6-16(12-14)25(27)28/h2-7,12-13H,8-11H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharma AG Curated by ChEMBL					Assay Description Inhibitory activity against Phosphodiesterase 4C (PDE4C) from human source expressed in Saccharomyces cerevisiae				J Med Chem 43: 675-82 (2000) BindingDB Entry DOI: 10.7270/Q2N58N3G
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (RAT)	BDBM50085134 ((4-Methyl-piperazin-1-yl)-[8-(3-nitro-phenyl)-[1,7...) Show SMILES CN1CCN(CC1)C(=O)c1cc2cccnc2c(n1)-c1cccc(c1)[N+]([O-])=O Show InChI InChI=1S/C20H19N5O3/c1-23-8-10-24(11-9-23)20(26)17-13-15-5-3-7-21-18(15)19(22-17)14-4-2-6-16(12-14)25(27)28/h2-7,12-13H,8-11H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	9.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharma AG Curated by ChEMBL					Assay Description Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiae				J Med Chem 43: 675-82 (2000) BindingDB Entry DOI: 10.7270/Q2N58N3G
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM50085134 ((4-Methyl-piperazin-1-yl)-[8-(3-nitro-phenyl)-[1,7...) Show SMILES CN1CCN(CC1)C(=O)c1cc2cccnc2c(n1)-c1cccc(c1)[N+]([O-])=O Show InChI InChI=1S/C20H19N5O3/c1-23-8-10-24(11-9-23)20(26)17-13-15-5-3-7-21-18(15)19(22-17)14-4-2-6-16(12-14)25(27)28/h2-7,12-13H,8-11H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharma AG Curated by ChEMBL					Assay Description Inhibitory activity against Phosphodiesterase 4A (PDE4A) from human source expressed in Saccharomyces cerevisiae				J Med Chem 43: 675-82 (2000) BindingDB Entry DOI: 10.7270/Q2N58N3G
					More data for this Ligand-Target Pair