BDBM50085143 CHEMBL158286::Trifluoro-methanesulfonic acid 8-(3-cyano-phenyl)-[1,7]naphthyridin-6-yl ester

SMILES: FC(F)(F)S(=O)(=O)Oc1cc2cccnc2c(n1)-c1cccc(c1)C#N

InChI Key: InChIKey=CWZPJPLVHJFENV-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50085143   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM50085143 (CHEMBL158286 | Trifluoro-methanesulfonic acid 8-(3...) Show SMILES FC(F)(F)S(=O)(=O)Oc1cc2cccnc2c(n1)-c1cccc(c1)C#N Show InChI InChI=1S/C16H8F3N3O3S/c17-16(18,19)26(23,24)25-13-8-12-5-2-6-21-14(12)15(22-13)11-4-1-3-10(7-11)9-20/h1-8H	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	770	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharma AG Curated by ChEMBL					Assay Description Inhibitory activity against Phosphodiesterase 4A (PDE4A) from human source expressed in Saccharomyces cerevisiae				J Med Chem 43: 675-82 (2000) BindingDB Entry DOI: 10.7270/Q2N58N3G
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (RAT)	BDBM50085143 (CHEMBL158286 | Trifluoro-methanesulfonic acid 8-(3...) Show SMILES FC(F)(F)S(=O)(=O)Oc1cc2cccnc2c(n1)-c1cccc(c1)C#N Show InChI InChI=1S/C16H8F3N3O3S/c17-16(18,19)26(23,24)25-13-8-12-5-2-6-21-14(12)15(22-13)11-4-1-3-10(7-11)9-20/h1-8H	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	420	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharma AG Curated by ChEMBL					Assay Description Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiae				J Med Chem 43: 675-82 (2000) BindingDB Entry DOI: 10.7270/Q2N58N3G
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50085143 (CHEMBL158286 | Trifluoro-methanesulfonic acid 8-(3...) Show SMILES FC(F)(F)S(=O)(=O)Oc1cc2cccnc2c(n1)-c1cccc(c1)C#N Show InChI InChI=1S/C16H8F3N3O3S/c17-16(18,19)26(23,24)25-13-8-12-5-2-6-21-14(12)15(22-13)11-4-1-3-10(7-11)9-20/h1-8H	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharma AG Curated by ChEMBL					Assay Description Inhibitory activity against Phosphodiesterase 4D (PDE4D) from human source expressed in Saccharomyces cerevisiae				J Med Chem 43: 675-82 (2000) BindingDB Entry DOI: 10.7270/Q2N58N3G
					More data for this Ligand-Target Pair
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50085143 (CHEMBL158286 | Trifluoro-methanesulfonic acid 8-(3...) Show SMILES FC(F)(F)S(=O)(=O)Oc1cc2cccnc2c(n1)-c1cccc(c1)C#N Show InChI InChI=1S/C16H8F3N3O3S/c17-16(18,19)26(23,24)25-13-8-12-5-2-6-21-14(12)15(22-13)11-4-1-3-10(7-11)9-20/h1-8H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	6.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharma AG Curated by ChEMBL					Assay Description Inhibitory activity against Phosphodiesterase 4C (PDE4C) from human source expressed in Saccharomyces cerevisiae				J Med Chem 43: 675-82 (2000) BindingDB Entry DOI: 10.7270/Q2N58N3G
					More data for this Ligand-Target Pair