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BDBM50086319 CHEMBL3426191

SMILES: NC(=O)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncs1

InChI Key: InChIKey=WJIVDQUOECKURQ-AULYBMBSNA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50086319   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lymphocyte differentiation antigen CD38


(Homo sapiens)
BDBM50086319
PNG
(CHEMBL3426191)
Show SMILES NC(=O)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1/C18H19N5OS/c19-17(24)11-1-4-13(5-2-11)23-18-14-7-12(16-8-20-10-25-16)3-6-15(14)21-9-22-18/h3,6-11,13H,1-2,4-5H2,(H2,19,24)(H,21,22,23)/t11-,13-
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 78n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)

More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086319
PNG
(CHEMBL3426191)
Show SMILES NC(=O)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1/C18H19N5OS/c19-17(24)11-1-4-13(5-2-11)23-18-14-7-12(16-8-20-10-25-16)3-6-15(14)21-9-22-18/h3,6-11,13H,1-2,4-5H2,(H2,19,24)(H,21,22,23)/t11-,13-
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 9n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)

More data for this
Ligand-Target Pair