BindingDB PrimarySearch

BDBM50086502 2-BFi::2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole::CHEMBL404505

SMILES: C1CN=C(N1)c1cc2ccccc2o1

InChI Key: InChIKey=YTJOHEUHUVBKSB-UHFFFAOYSA-N

Data: 16 KI 3 IC50 1 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50086502
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Nischarin (Homo sapiens (Human))	BDBM50086502 (2-BFi \| 2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole...) Show SMILES C1CN=C(N1)c1cc2ccccc2o1 \|c:2\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ d'Orl£ans Curated by ChEMBL					Assay Description Binding affinity for imidazoline receptor I-2 in rabbit kidney homogenate (relative to [3H]-Idazoxan radioligand)				J Med Chem 43: 1109-22 (2000) Article DOI: 10.1021/jm991124t BindingDB Entry DOI: 10.7270/Q2SB48G9
Universit£ d'Orl£ans Curated by ChEMBL					More data for this Ligand-Target Pair
Imidazoline receptor 1 (I1R) (Homo sapiens (Human))	BDBM50086502 (2-BFi \| 2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole...) Show SMILES C1CN=C(N1)c1cc2ccccc2o1 \|c:2\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Binding affinity for rat imidazoline receptor I-1 from crude P2 membranes				Bioorg Med Chem Lett 14: 527-9 (2003) BindingDB Entry DOI: 10.7270/Q20G3JKT
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor (Homo sapiens)	BDBM50086502 (2-BFi \| 2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole...) Show SMILES C1CN=C(N1)c1cc2ccccc2o1 \|c:2\| Show InChI	MMDB B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Barcelona Curated by ChEMBL					Assay Description Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry				J Med Chem 63: 3610-3633 (2020) Article DOI: 10.1021/acs.jmedchem.9b02080
University of Barcelona Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic receptor alpha-2 (RAT-NEONATAL RAT-Rattus norvegicus (rat))	BDBM50086502 (2-BFi \| 2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole...) Show SMILES C1CN=C(N1)c1cc2ccccc2o1 \|c:2\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Inhibition of 1 nM [3H]RX-821002 binding to rat whole brain membrane Alpha-2 adrenergic receptors				Bioorg Med Chem Lett 10: 605-7 (2000) BindingDB Entry DOI: 10.7270/Q2PR7V63
University of Bristol Curated by ChEMBL					More data for this Ligand-Target Pair
Monoamine Oxidase Type B (MAO-B) (Rattus norvegicus (rat))	BDBM50086502 (2-BFi \| 2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole...) Show SMILES C1CN=C(N1)c1cc2ccccc2o1 \|c:2\| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3.63E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal de Santa Maria Curated by ChEMBL					Assay Description Binding affinity to MAOB imidazoline binding site in rat brain mitochondrial homogenate assessed as 4-hydroxyquinoline production by spectrophotometr...				Bioorg Med Chem Lett 19: 546-9 (2008) Article DOI: 10.1016/j.bmcl.2008.03.001 BindingDB Entry DOI: 10.7270/Q2251J2V
Universidade Federal de Santa Maria Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic receptor alpha-2 (RAT-NEONATAL RAT-Rattus norvegicus (rat))	BDBM50086502 (2-BFi \| 2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole...) Show SMILES C1CN=C(N1)c1cc2ccccc2o1 \|c:2\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3.98E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Camerino Curated by ChEMBL					Assay Description Displacement of [3H]RX821002 from alpha2 adrenergic receptor in rat brain membrane				Bioorg Med Chem 18: 7085-91 (2010) Article DOI: 10.1016/j.bmc.2010.08.005 BindingDB Entry DOI: 10.7270/Q2KP850W
Universit£ degli Studi di Camerino Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic receptor alpha-2 (RAT-NEONATAL RAT-Rattus norvegicus (rat))	BDBM50086502 (2-BFi \| 2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole...) Show SMILES C1CN=C(N1)c1cc2ccccc2o1 \|c:2\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Binding affinity for rat alpha-2 adrenergic receptor from crude P2 membranes				Bioorg Med Chem Lett 14: 527-9 (2003) BindingDB Entry DOI: 10.7270/Q20G3JKT
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic receptor alpha-2 (RAT-NEONATAL RAT-Rattus norvegicus (rat))	BDBM50086502 (2-BFi \| 2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole...) Show SMILES C1CN=C(N1)c1cc2ccccc2o1 \|c:2\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Displacement of [3H]RX-821002 from alpha-2 adrenergic receptor				Bioorg Med Chem Lett 14: 1003-5 (2004) Article DOI: 10.1016/j.bmcl.2003.12.033 BindingDB Entry DOI: 10.7270/Q2NK3DGR
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] B (Homo sapiens (Human))	BDBM50086502 (2-BFi \| 2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole...) Show SMILES C1CN=C(N1)c1cc2ccccc2o1 \|c:2\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	8.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ushinsky Yaroslavl State Pedagogical University Curated by ChEMBL					Assay Description Competitive inhibition of human MAOB using farnesylamine as substrate preincubated with substrate for 5 mins followed by enzyme addition by fluorimet...				Bioorg Med Chem Lett 29: 40-46 (2019) Article DOI: 10.1016/j.bmcl.2018.11.018
					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] B (Homo sapiens (Human))	BDBM50086502 (2-BFi \| 2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole...) Show SMILES C1CN=C(N1)c1cc2ccccc2o1 \|c:2\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	8.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Hefei University of Technology Curated by ChEMBL					Assay Description Competitive inhibition of recombinant human MAO-B using farnesylamine as substrate by horseradish peroxidase-Amplex red-coupled assay				Eur J Med Chem 145: 588-593 (2018) Article DOI: 10.1016/j.ejmech.2018.01.029 BindingDB Entry DOI: 10.7270/Q2JD50CJ
Hefei University of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Amine oxidase (flavin-containing) A (Homo sapiens (Human))	BDBM50086502 (2-BFi \| 2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole...) Show SMILES C1CN=C(N1)c1cc2ccccc2o1 \|c:2\| Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ushinsky Yaroslavl State Pedagogical University Curated by ChEMBL					Assay Description Competitive inhibition of human MAOA using p-trifluoromethyl benzylamine as substrate preincubated with substrate for 5 mins followed by enzyme addit...				Bioorg Med Chem Lett 29: 40-46 (2019) Article DOI: 10.1016/j.bmcl.2018.11.018
					More data for this Ligand-Target Pair
Monoamine oxidase (Rattus norvegicus (rat))	BDBM50086502 (2-BFi \| 2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole...) Show SMILES C1CN=C(N1)c1cc2ccccc2o1 \|c:2\| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.49E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal de Santa Maria Curated by ChEMBL					Assay Description Binding affinity to MAOA imidazoline binding site in rat brain mitochondrial homogenate assessed as 4-hydroxyquinoline production by spectrophotometr...				Bioorg Med Chem Lett 19: 546-9 (2008) Article DOI: 10.1016/j.bmcl.2008.03.001 BindingDB Entry DOI: 10.7270/Q2251J2V
Universidade Federal de Santa Maria Curated by ChEMBL					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] B (Homo sapiens (Human))	BDBM50086502 (2-BFi \| 2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole...) Show SMILES C1CN=C(N1)c1cc2ccccc2o1 \|c:2\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.60E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal de Santa Maria Curated by ChEMBL					Assay Description Binding affinity to human MAOB imidazoline binding site				Bioorg Med Chem Lett 19: 546-9 (2008) Article DOI: 10.1016/j.bmcl.2008.03.001 BindingDB Entry DOI: 10.7270/Q2251J2V
Universidade Federal de Santa Maria Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor (Homo sapiens (Human))	BDBM50086502 (2-BFi \| 2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole...) Show SMILES C1CN=C(N1)c1cc2ccccc2o1 \|c:2\| Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.69E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Camerino Curated by ChEMBL					Assay Description Binding affinity at human alpha2A AR				ACS Med Chem Lett 4: 875-9 (2013) Article DOI: 10.1021/ml400232p BindingDB Entry DOI: 10.7270/Q2H134ZZ
University of Camerino Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic receptor (Homo sapiens (Human))	BDBM50086502 (2-BFi \| 2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole...) Show SMILES C1CN=C(N1)c1cc2ccccc2o1 \|c:2\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.69E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Camerino Curated by ChEMBL					Assay Description Binding affinity at human alpha2B AR				ACS Med Chem Lett 4: 875-9 (2013) Article DOI: 10.1021/ml400232p BindingDB Entry DOI: 10.7270/Q2H134ZZ
University of Camerino Curated by ChEMBL					More data for this Ligand-Target Pair
Adrenergic receptor (Homo sapiens (Human))	BDBM50086502 (2-BFi \| 2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole...) Show SMILES C1CN=C(N1)c1cc2ccccc2o1 \|c:2\| Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.69E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Camerino Curated by ChEMBL					Assay Description Binding affinity at human alpha2C AR				ACS Med Chem Lett 4: 875-9 (2013) Article DOI: 10.1021/ml400232p BindingDB Entry DOI: 10.7270/Q2H134ZZ
University of Camerino Curated by ChEMBL					More data for this Ligand-Target Pair
Monoamine Oxidase Type B (MAO-B) (Rattus norvegicus (rat))	BDBM50086502 (2-BFi \| 2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole...) Show SMILES C1CN=C(N1)c1cc2ccccc2o1 \|c:2\| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal de Santa Maria Curated by ChEMBL					Assay Description Binding affinity to MAOB imidazoline binding site in rat brain mitochondrial homogenate assessed as 4-hydroxyquinoline production by spectrophotometr...				Bioorg Med Chem Lett 19: 546-9 (2008) Article DOI: 10.1016/j.bmcl.2008.03.001 BindingDB Entry DOI: 10.7270/Q2251J2V
Universidade Federal de Santa Maria Curated by ChEMBL					More data for this Ligand-Target Pair
Imidazoline receptor 1 (I1R) (Homo sapiens (Human))	BDBM50086502 (2-BFi \| 2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole...) Show SMILES C1CN=C(N1)c1cc2ccccc2o1 \|c:2\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	6.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Inhibition of 3 nM [3H]-clonidine binding to rat kidney membrane imidazoline receptor I-1 in presence of rauwolscine				Bioorg Med Chem Lett 10: 605-7 (2000) BindingDB Entry DOI: 10.7270/Q2PR7V63
University of Bristol Curated by ChEMBL					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] B (Homo sapiens (Human))	BDBM50086502 (2-BFi \| 2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole...) Show SMILES C1CN=C(N1)c1cc2ccccc2o1 \|c:2\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a
Ushinsky Yaroslavl State Pedagogical University Curated by ChEMBL					Assay Description Inhibition of tranylcypromine binding to human MAOB by fluorescence assay				Bioorg Med Chem Lett 29: 40-46 (2019) Article DOI: 10.1016/j.bmcl.2018.11.018
					More data for this Ligand-Target Pair
Monoamine oxidase (Rattus norvegicus (rat))	BDBM50086502 (2-BFi \| 2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole...) Show SMILES C1CN=C(N1)c1cc2ccccc2o1 \|c:2\| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal de Santa Maria Curated by ChEMBL					Assay Description Binding affinity to MAOA imidazoline binding site in rat brain mitochondrial homogenate assessed as 4-hydroxyquinoline production by spectrophotometr...				Bioorg Med Chem Lett 19: 546-9 (2008) Article DOI: 10.1016/j.bmcl.2008.03.001 BindingDB Entry DOI: 10.7270/Q2251J2V
Universidade Federal de Santa Maria Curated by ChEMBL					More data for this Ligand-Target Pair