BDBM50087003 8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-(2-hydroxy-ethyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one::CHEMBL26987

SMILES: OCCN1CN(c2ccccc2)C2(CCN(CC2)C2CCc3cccc(Cl)c3C2)C1=O

InChI Key: InChIKey=WYIKDGQRKDCMOA-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50087003   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50087003 (8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-...) Show SMILES OCCN1CN(c2ccccc2)C2(CCN(CC2)C2CCc3cccc(Cl)c3C2)C1=O Show InChI InChI=1S/C25H30ClN3O2/c26-23-8-4-5-19-9-10-21(17-22(19)23)27-13-11-25(12-14-27)24(31)28(15-16-30)18-29(25)20-6-2-1-3-7-20/h1-8,21,30H,9-18H2	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor mu 1				J Med Chem 43: 1329-38 (2001) BindingDB Entry DOI: 10.7270/Q2ZG6SZG
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50087003 (8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-...) Show SMILES OCCN1CN(c2ccccc2)C2(CCN(CC2)C2CCc3cccc(Cl)c3C2)C1=O Show InChI InChI=1S/C25H30ClN3O2/c26-23-8-4-5-19-9-10-21(17-22(19)23)27-13-11-25(12-14-27)24(31)28(15-16-30)18-29(25)20-6-2-1-3-7-20/h1-8,21,30H,9-18H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	7.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Effective concentration required to stimulate binding of GTPgammaS to Opioid receptor like 1 was determined using scintillation proximity assay				J Med Chem 43: 1329-38 (2001) BindingDB Entry DOI: 10.7270/Q2ZG6SZG
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50087003 (8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-...) Show SMILES OCCN1CN(c2ccccc2)C2(CCN(CC2)C2CCc3cccc(Cl)c3C2)C1=O Show InChI InChI=1S/C25H30ClN3O2/c26-23-8-4-5-19-9-10-21(17-22(19)23)27-13-11-25(12-14-27)24(31)28(15-16-30)18-29(25)20-6-2-1-3-7-20/h1-8,21,30H,9-18H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1				J Med Chem 43: 1329-38 (2001) BindingDB Entry DOI: 10.7270/Q2ZG6SZG
					More data for this Ligand-Target Pair
Delta-type opioid receptor (Homo sapiens (Human))	BDBM50087003 (8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-...) Show SMILES OCCN1CN(c2ccccc2)C2(CCN(CC2)C2CCc3cccc(Cl)c3C2)C1=O Show InChI InChI=1S/C25H30ClN3O2/c26-23-8-4-5-19-9-10-21(17-22(19)23)27-13-11-25(12-14-27)24(31)28(15-16-30)18-29(25)20-6-2-1-3-7-20/h1-8,21,30H,9-18H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	285	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor delta 1				J Med Chem 43: 1329-38 (2001) BindingDB Entry DOI: 10.7270/Q2ZG6SZG
					More data for this Ligand-Target Pair