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BDBM50087275 CHEMBL3426644

SMILES: NCc1ccc(cc1-c1cccc(NC(=O)c2cccc(c2)C(O)=O)c1)C(=O)Nc1ccncc1F

InChI Key: InChIKey=DWGNOHCJHUKFMN-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50087275   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50087275
PNG
(CHEMBL3426644)
Show SMILES NCc1ccc(cc1-c1cccc(NC(=O)c2cccc(c2)C(O)=O)c1)C(=O)Nc1ccncc1F
Show InChI InChI=1S/C27H21FN4O4/c28-23-15-30-10-9-24(23)32-26(34)18-7-8-20(14-29)22(13-18)16-3-2-6-21(12-16)31-25(33)17-4-1-5-19(11-17)27(35)36/h1-13,15H,14,29H2,(H,31,33)(H,35,36)(H,30,32,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a<1n/an/an/an/an/an/a



Agoralaan Abis

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometr...


J Med Chem 58: 4309-24 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00308
BindingDB Entry DOI: 10.7270/Q2H41T4R
More data for this
Ligand-Target Pair