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BDBM50087559 CHEMBL164206::Cyclopropylmethyl-propyl-[2,5,6-trimethyl-7-(2,4,6-trimethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-amine

SMILES: CCCN(CC1CC1)c1nc(C)nc2n(c(C)c(C)c12)-c1c(C)cc(C)cc1C

InChI Key: InChIKey=BUUZKUBXYMPJOM-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50087559   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))		BDBM50087559
PNG
(CHEMBL164206 | Cyclopropylmethyl-propyl-[2,5,6-tri...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc2n(c(C)c(C)c12)-c1c(C)cc(C)cc1C |(2.88,-3.62,;4.39,-3.31,;5.41,-4.46,;6.91,-4.14,;7.4,-2.67,;6.37,-1.52,;6.03,-.01,;4.9,-1.05,;7.96,-5.28,;7.47,-6.74,;8.52,-7.89,;8.03,-9.36,;10.01,-7.57,;10.48,-6.1,;11.88,-5.48,;11.72,-3.95,;12.86,-2.92,;10.22,-3.62,;9.6,-2.22,;9.46,-4.95,;13.21,-6.25,;13.21,-7.79,;11.88,-8.56,;14.54,-8.56,;15.89,-7.79,;17.23,-8.56,;15.89,-6.24,;14.54,-5.47,;14.54,-3.93,)|
Show InChI InChI=1S/C25H34N4/c1-8-11-28(14-21-9-10-21)24-22-18(5)19(6)29(25(22)27-20(7)26-24)23-16(3)12-15(2)13-17(23)4/h12-13,21H,8-11,14H2,1-7H3
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PubMed
 2.30n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its ability to displace [125 I]Tyr-sauvagine from corticotropin-releasing hormone type 1 receptor in rat cerebellum

Bioorg Med Chem Lett 10: 707-10 (2000)


BindingDB Entry DOI: 10.7270/Q2SB44ZX
More data for this
Ligand-Target Pair