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BDBM50087561 Butyl-(4-fluoro-butyl)-[2,5,6-trimethyl-7-(2,4,6-trimethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-amine::CHEMBL163618

SMILES: CCCCN(CCCCF)c1nc(C)nc2n(c(C)c(C)c12)-c1c(C)cc(C)cc1C

InChI Key: InChIKey=HIQKZIGQVAJWFC-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50087561   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))		BDBM50087561
PNG
(Butyl-(4-fluoro-butyl)-[2,5,6-trimethyl-7-(2,4,6-t...)
Show SMILES CCCCN(CCCCF)c1nc(C)nc2n(c(C)c(C)c12)-c1c(C)cc(C)cc1C |(6.62,.32,;7.65,-.83,;7.16,-2.29,;8.19,-3.44,;7.72,-4.91,;6.2,-5.22,;5.18,-4.08,;3.67,-4.4,;2.64,-3.26,;1.13,-3.58,;8.75,-6.06,;8.28,-7.51,;9.31,-8.66,;8.85,-10.13,;10.81,-8.35,;11.29,-6.88,;12.7,-6.25,;12.54,-4.72,;13.69,-3.68,;11.02,-4.4,;10.4,-2.99,;10.26,-5.74,;14.04,-7.02,;14.04,-8.57,;12.7,-9.34,;15.37,-9.34,;16.7,-8.57,;18.05,-9.34,;16.7,-7.02,;15.37,-6.25,;15.36,-4.71,)|
Show InChI InChI=1S/C26H37FN4/c1-8-9-13-30(14-11-10-12-27)25-23-20(5)21(6)31(26(23)29-22(7)28-25)24-18(3)15-17(2)16-19(24)4/h15-16H,8-14H2,1-7H3
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PubMed
 10n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its ability to displace [125 I]Tyr-sauvagine from corticotropin-releasing hormone type 1 receptor in rat cerebellum

Bioorg Med Chem Lett 10: 707-10 (2000)


BindingDB Entry DOI: 10.7270/Q2SB44ZX
More data for this
Ligand-Target Pair