BDBM50088140 CHEMBL3427231::US9365511, 8

SMILES: C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(CCn2ncnn2)cc1

InChI Key: InChIKey=XKUCBPWVGMSFND-GOSISDBHSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50088140   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50088140 (CHEMBL3427231 | US9365511, 8) Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(CCn2ncnn2)cc1 |r| Show InChI InChI=1S/C22H27N5/c1-18-3-2-14-26(18)15-12-19-4-8-21(9-5-19)22-10-6-20(7-11-22)13-16-27-24-17-23-25-27/h4-11,17-18H,2-3,12-16H2,1H3/t18-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Temple University School of Pharmacy Curated by ChEMBL					Assay Description Modulation of human histamine H3 receptor expressed in HEK293 cells assessed as change in forskolin-stimulated cAMP level after 1 hr by HTRF assay				ACS Med Chem Lett 6: 235-6 (2015) Article DOI: 10.1021/acsmedchemlett.5b00002 BindingDB Entry DOI: 10.7270/Q2PN97B5
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50088140 (CHEMBL3427231 | US9365511, 8) Show SMILES C[C@@H]1CCCN1CCc1ccc(cc1)-c1ccc(CCn2ncnn2)cc1 |r| Show InChI InChI=1S/C22H27N5/c1-18-3-2-14-26(18)15-12-19-4-8-21(9-5-19)22-10-6-20(7-11-22)13-16-27-24-17-23-25-27/h4-11,17-18H,2-3,12-16H2,1H3/t18-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
ARENA PHARMACEUTICALS, INC. US Patent					Assay Description Compounds of the present invention were evaluated using the human H3 receptor (H3R) HTRF cAMP assay. In this assay, HEK293 cells expressing the human...				US Patent US9365511 (2016) BindingDB Entry DOI: 10.7270/Q2FJ2FP8
					More data for this Ligand-Target Pair