BDBM50088213 (2S,4R)-4-allyl glutamate::2-Allyl-4-amino-pentanedioic acid(LY310214)::CHEMBL62057::LY-310214
SMILES: N[C@@H](C[C@@H](CC=C)C(O)=O)C(O)=O
InChI Key: InChIKey=APFSBOCBNKHACW-RITPCOANSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GRIK1 (Homo sapiens (Human)) | BDBM50088213 ((2S,4R)-4-allyl glutamate | 2-Allyl-4-amino-pentan...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 56 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly, S.A. Curated by ChEMBL | Assay Description Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand | J Med Chem 43: 1958-68 (2000) BindingDB Entry DOI: 10.7270/Q2FX78QB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, kainate 2 (Homo sapiens (Human)) | BDBM50088213 ((2S,4R)-4-allyl glutamate | 2-Allyl-4-amino-pentan...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.84E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly, S.A. Curated by ChEMBL | Assay Description compound was tested for binding affinity against human Ionotropic glutamate receptor ionotropic kainate 2 in HK293 cells using [3H]-kainate as radiol... | J Med Chem 43: 1958-68 (2000) BindingDB Entry DOI: 10.7270/Q2FX78QB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, kainate 2 (Homo sapiens (Human)) | BDBM50088213 ((2S,4R)-4-allyl glutamate | 2-Allyl-4-amino-pentan...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a |
University of California Berkeley Curated by ChEMBL | Assay Description Agonist activity at iGluR6 L439C mutant expressed in human HEK293 cells assessed as increase in intracellular Ca2+ levels by FURA-2-M staining based ... | Nat Chem Biol 2: 47-52 (2006) Article DOI: 10.1038/nchembio756 BindingDB Entry DOI: 10.7270/Q2JS9T8F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GRIK1 (Homo sapiens (Human)) | BDBM50088213 ((2S,4R)-4-allyl glutamate | 2-Allyl-4-amino-pentan...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a |
Lilly, S.A. Curated by ChEMBL | Assay Description Effective concentration of the compound required for evoking response in HEK293 cell | J Med Chem 43: 1958-68 (2000) BindingDB Entry DOI: 10.7270/Q2FX78QB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate receptor ionotropic, kainate 2 (Homo sapiens (Human)) | BDBM50088213 ((2S,4R)-4-allyl glutamate | 2-Allyl-4-amino-pentan...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 8.30E+3 | n/a | n/a | n/a | n/a |
Lilly, S.A. Curated by ChEMBL | Assay Description Effective concentration against human GluR6 expressed in HEK293 cells | J Med Chem 43: 1958-68 (2000) BindingDB Entry DOI: 10.7270/Q2FX78QB | |||||||||||
More data for this Ligand-Target Pair |