BDBM50088375 1-{8-[(2,3-Diphenyl-cycloprop-2-enecarbonyl)-methyl-amino]-1-oxa-spiro[4.5]dec-7-yl}-pyrrolidinium
SMILES: CN([C@H]1CC[C@@]2(CCCO2)C[C@@H]1[NH+]1CCCC1)C(=O)C1C(=C1c1ccccc1)c1ccccc1
InChI Key: InChIKey=DVBJTNONUUBBIZ-QRQMUESOSA-O
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Kappa-type opioid receptor (Rattus norvegicus (rat)) | BDBM50088375 (1-{8-[(2,3-Diphenyl-cycloprop-2-enecarbonyl)-methy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | 0.640 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Napoli"Federico II" Curated by ChEMBL | Assay Description Inhibition of [3H]- U-69593 binding in cloned rat Opioid receptor kappa 1 expressed in CHO cell line | J Med Chem 43: 2124-34 (2000) BindingDB Entry DOI: 10.7270/Q23N242D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Rattus norvegicus (rat)) | BDBM50088375 (1-{8-[(2,3-Diphenyl-cycloprop-2-enecarbonyl)-methy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article | 0.640 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of binding of [3H]-U-69,593 to cloned rat Opioid receptor kappa 1 expressed in CHO cell line | Bioorg Med Chem Lett 7: 291-296 (1997) Article DOI: 10.1016/S0960-894X(96)00615-4 BindingDB Entry DOI: 10.7270/Q2G160VS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Rattus norvegicus (rat)) | BDBM50088375 (1-{8-[(2,3-Diphenyl-cycloprop-2-enecarbonyl)-methy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of binding of [3H]-DAGO to rat brain mu opioid receptor | Bioorg Med Chem Lett 7: 291-296 (1997) Article DOI: 10.1016/S0960-894X(96)00615-4 BindingDB Entry DOI: 10.7270/Q2G160VS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50088375 (1-{8-[(2,3-Diphenyl-cycloprop-2-enecarbonyl)-methy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article | n/a | n/a | n/a | n/a | 9.60 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of Opioid receptor kappa 1 as reduced contraction in electrically stimulated rabbit vas deferens | Bioorg Med Chem Lett 7: 291-296 (1997) Article DOI: 10.1016/S0960-894X(96)00615-4 BindingDB Entry DOI: 10.7270/Q2G160VS | |||||||||||
More data for this Ligand-Target Pair |